Cargando…

Antimicrobial and Cytotoxic Activities of Water-Soluble Isoxazole-Linked 1,3,4-Oxadiazole with Delocalized Charge: In Vitro and In Vivo Results

The distinct structure of cationic organic compounds plays a pivotal role in enhancing their water solubility, which in turn influences their bioavailability. A representative of these compounds, which contains a delocalized charge, is 5-amino-2-(5-amino-3-methyl-1,2-oxazol-4-yl)-3-methyl-2,3-dihydr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dudek, Bartłomiej, Bąchor, Urszula, Drozd-Szczygieł, Ewa, Brożyna, Malwina, Dąbrowski, Piotr, Junka, Adam, Mączyński, Marcin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671643/ https://www.ncbi.nlm.nih.gov/pubmed/38003222 http://dx.doi.org/10.3390/ijms242216033

Ejemplares similares

New water-soluble isoxazole-linked 1,3,4-oxadiazole derivative with delocalized positive charge
por: Bąchor, Urszula, et al.
Publicado: (2021)

The In Vitro Impact of Isoxazole Derivatives on Pathogenic Biofilm and Cytotoxicity of Fibroblast Cell Line
por: Bąchor, Urszula, et al.
Publicado: (2023)

Isoxazole Derivatives as Regulators of Immune Functions
por: Zimecki, Michał, et al.
Publicado: (2018)

5-Amino-3-methyl-Isoxazole-4-carboxylic Acid as a Novel Unnatural Amino Acid in the Solid Phase Synthesis of α/β-Mixed Peptides
por: Bąchor, Urszula, et al.
Publicado: (2022)

A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation
por: Basavanna, V., et al.
Publicado: (2021)

Selected β(2)-, β(3)- and β(2,3)-Amino Acid Heterocyclic Derivatives and Their Biological Perspective
por: Bąchor, Urszula, et al.
Publicado: (2021)

Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles
por: Desai, N.C., et al.
Publicado: (2013)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

Enhancement of intramolecular charge transfer strength in diphenylamine substituted symmetric 1,3,4-oxadiazole derivatives
por: Chen, Fangyi, et al.
Publicado: (2018)

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors
por: Kumar, Davinder, et al.
Publicado: (2023)

Preclinical Study of Immunological Isoxazole Derivatives as a Potential Support for Melanoma Chemotherapy
por: Jęśkowiak, Izabela, et al.
Publicado: (2021)

5-Phenyl-1,3,4-oxadiazol-2-amine
por: Song, Man-Man, et al.
Publicado: (2012)

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
por: Glomb, Teresa, et al.
Publicado: (2018)

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
por: Wang, Qian, et al.
Publicado: (2019)

1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1
por: Carbone, Daniela, et al.
Publicado: (2023)

Synthesis, Immunosuppressive Properties, and Mechanism of Action of a New Isoxazole Derivative
por: Mączyński, Marcin, et al.
Publicado: (2018)

The Medium Composition Impacts Staphylococcus aureus Biofilm Formation and Susceptibility to Antibiotics Applied in the Treatment of Bone Infections
por: Paleczny, Justyna, et al.
Publicado: (2022)

The Assessment of Activity of Antiseptic Agents against Biofilm of Staphylococcus aureus Measured with the Use of Processed Microscopic Images
por: Krasowski, Grzegorz, et al.
Publicado: (2022)

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
por: Aksenov, Alexander V., et al.
Publicado: (2019)

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives
por: Stecoza, Camelia Elena, et al.
Publicado: (2021)

The In Vitro Ability of Klebsiella pneumoniae to Form Biofilm and the Potential of Various Compounds to Eradicate It from Urinary Catheters
por: Oleksy-Wawrzyniak, Monika, et al.
Publicado: (2021)

Charge delocalization characteristics of regioregular high mobility polymers
por: Coughlin, J. E., et al.
Publicado: (2017)

The Antimicrobial and Antibiofilm In Vitro Activity of Liquid and Vapour Phases of Selected Essential Oils against Staphylococcus aureus
por: Brożyna, Malwina, et al.
Publicado: (2021)

2-[3,4-Dibutoxy-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-2-thienyl]-5-phenyl-1,3,4-oxadiazole
por: Li, Hai-lin, et al.
Publicado: (2008)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
por: Wang, Jing-Jing, et al.
Publicado: (2022)

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole
por: Cordes, David B., et al.
Publicado: (2011)

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
por: Bhat, KI, et al.
Publicado: (2011)

Trifluoromethylpyridine 1,3,4-Oxadiazole Derivatives: Emerging Scaffolds as Bacterial Agents
por: Yu, Gang, et al.
Publicado: (2021)

Quantum localization and delocalization of charge carriers in organic semiconducting crystals
por: Giannini, Samuele, et al.
Publicado: (2019)

Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles
por: Nagalakshmi, G.
Publicado: (2008)

5-(4-Methylphenyl)-1,3,4-oxadiazol-2-amine
por: Zheng, Juan, et al.
Publicado: (2012)

2,6-Dimethyl-4-(1,3,4-oxadiazol-2-yl)quinoline
por: Kashaev, Artyom G., et al.
Publicado: (2010)

Synthesis and Biological Evaluation of β-Aroylpropionic acid based 1,3,4-Oxadiazoles
por: Husain, A., et al.
Publicado: (2009)

Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
por: Wu, Jian, et al.
Publicado: (2013)

1,3,4-Oxadiazole Derivatives: Synthesis, Characterization, Antimicrobial Potential, and Computational Studies
por: Bala, Suman, et al.
Publicado: (2014)

Novel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs
por: Durgashivaprasad, Ega, et al.
Publicado: (2014)

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives
por: Batool, Majda, et al.
Publicado: (2018)

Synthesis and Bioassay of a New Class of Furanyl-1,3,4-Oxadiazole Derivatives
por: El Sadek, Mohamed M., et al.
Publicado: (2013)

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment
por: Rasras, Anas J, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r2bl8bba3ldrgsoa350lnebt34