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Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mech...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671803/ https://www.ncbi.nlm.nih.gov/pubmed/38003708 http://dx.doi.org/10.3390/ijms242216518 |
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author | Katoh, Kazuo |
author_facet | Katoh, Kazuo |
author_sort | Katoh, Kazuo |
collection | PubMed |
description | Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mechanical stresses, both in situ and in vitro, affect endothelial cells. We review the basic principles underlying the cellular response to mechanical stresses. We also consider the implications of these findings for understanding the mechanisms of mechanotransducer and mechano-signal transduction systems by cytoskeletal components. |
format | Online Article Text |
id | pubmed-10671803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106718032023-11-20 Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro Katoh, Kazuo Int J Mol Sci Review Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mechanical stresses, both in situ and in vitro, affect endothelial cells. We review the basic principles underlying the cellular response to mechanical stresses. We also consider the implications of these findings for understanding the mechanisms of mechanotransducer and mechano-signal transduction systems by cytoskeletal components. MDPI 2023-11-20 /pmc/articles/PMC10671803/ /pubmed/38003708 http://dx.doi.org/10.3390/ijms242216518 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Katoh, Kazuo Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title | Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title_full | Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title_fullStr | Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title_full_unstemmed | Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title_short | Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro |
title_sort | effects of mechanical stress on endothelial cells in situ and in vitro |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671803/ https://www.ncbi.nlm.nih.gov/pubmed/38003708 http://dx.doi.org/10.3390/ijms242216518 |
work_keys_str_mv | AT katohkazuo effectsofmechanicalstressonendothelialcellsinsituandinvitro |