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Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro

Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mech...

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Detalles Bibliográficos
Autor principal: Katoh, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671803/
https://www.ncbi.nlm.nih.gov/pubmed/38003708
http://dx.doi.org/10.3390/ijms242216518
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author Katoh, Kazuo
author_facet Katoh, Kazuo
author_sort Katoh, Kazuo
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description Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mechanical stresses, both in situ and in vitro, affect endothelial cells. We review the basic principles underlying the cellular response to mechanical stresses. We also consider the implications of these findings for understanding the mechanisms of mechanotransducer and mechano-signal transduction systems by cytoskeletal components.
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spelling pubmed-106718032023-11-20 Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro Katoh, Kazuo Int J Mol Sci Review Endothelial cells lining blood vessels are essential for maintaining vascular homeostasis and mediate several pathological and physiological processes. Mechanical stresses generated by blood flow and other biomechanical factors significantly affect endothelial cell activity. Here, we review how mechanical stresses, both in situ and in vitro, affect endothelial cells. We review the basic principles underlying the cellular response to mechanical stresses. We also consider the implications of these findings for understanding the mechanisms of mechanotransducer and mechano-signal transduction systems by cytoskeletal components. MDPI 2023-11-20 /pmc/articles/PMC10671803/ /pubmed/38003708 http://dx.doi.org/10.3390/ijms242216518 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Katoh, Kazuo
Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title_full Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title_fullStr Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title_full_unstemmed Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title_short Effects of Mechanical Stress on Endothelial Cells In Situ and In Vitro
title_sort effects of mechanical stress on endothelial cells in situ and in vitro
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671803/
https://www.ncbi.nlm.nih.gov/pubmed/38003708
http://dx.doi.org/10.3390/ijms242216518
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