Cargando…

Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions

The underlying genetic susceptibility for Alzheimer’s disease (AD) is not yet fully understood. The heterogeneous nature of the disease challenges genetic association studies. Endophenotype approaches can help to address this challenge by more direct interrogation of biological traits related to the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosewood, Thea J., Nho, Kwangsik, Risacher, Shannon L., Gao, Sujuan, Shen, Li, Foroud, Tatiana, Saykin, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671827/ https://www.ncbi.nlm.nih.gov/pubmed/38002954 http://dx.doi.org/10.3390/genes14112010

Ejemplares similares

Deep learning detection of informative features in tau PET for Alzheimer’s disease classification
por: Jo, Taeho, et al.
Publicado: (2020)

Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
por: Hirschfeld, Lauren Rose, et al.
Publicado: (2022)

Association of the top 20 Alzheimer's disease risk genes with [(18)F]flortaucipir PET
por: Stage, Eddie, et al.
Publicado: (2022)

Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer’s disease
por: Lee, Younghee, et al.
Publicado: (2018)

Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus
por: Han, Seonggyun, et al.
Publicado: (2019)

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease
por: Yan, Jingwen, et al.
Publicado: (2015)

Genetics and Genomics of Late-Onset Alzheimer's Disease and Its Endophenotypes
por: Reitz, Christiane, et al.
Publicado: (2011)

From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs
por: Wang, Hua, et al.
Publicado: (2012)

Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data
por: Jo, Taeho, et al.
Publicado: (2019)

Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease
por: Miller, Jason E., et al.
Publicado: (2018)

Integration of bioinformatics and imaging informatics for identifying rare PSEN1 variants in Alzheimer’s disease
por: Nho, Kwangsik, et al.
Publicado: (2016)

Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
por: Varathan, Pradeep, et al.
Publicado: (2022)

Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants
por: Li, Wei, et al.
Publicado: (2017)

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways
por: Horgusluoglu-Moloch, Emrin, et al.
Publicado: (2019)

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease
por: Nho, Kwangsik, et al.
Publicado: (2017)

Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer’s disease
por: Kim, Mansu, et al.
Publicado: (2022)

Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer’s disease
por: Upadhyaya, Yurika, et al.
Publicado: (2020)

Association of cancer history with Alzheimer's disease onset and structural brain changes
por: Nudelman, Kelly N. H., et al.
Publicado: (2014)

The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism
por: Stage, Eddie, et al.
Publicado: (2016)

Fused multi-modal similarity network as prior in guiding brain imaging genetic association
por: He, Bing, et al.
Publicado: (2023)

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso
por: Xie, Linhui, et al.
Publicado: (2020)

Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort
por: Swaminathan, Shanker, et al.
Publicado: (2011)

Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease
por: Kim, Bo‐Hyun, et al.
Publicado: (2022)

Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2023)

Neuroimaging Measures as Endophenotypes in Alzheimer's Disease
por: Braskie, Meredith N., et al.
Publicado: (2011)

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
por: Ramanan, Vijay K., et al.
Publicado: (2013)

Association of peripheral blood DNA methylation level with Alzheimer’s disease progression
por: Li, Qingqin S., et al.
Publicado: (2021)

White matter alterations in early-stage Alzheimer's disease: A tract-specific study
por: Wen, Qiuting, et al.
Publicado: (2019)

Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
por: Swaminathan, Shanker, et al.
Publicado: (2011)

Cognitive biomarker prioritization in Alzheimer’s Disease using brain morphometric data
por: Peng, Bo, et al.
Publicado: (2020)

Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition
por: Swinford, Cecily G., et al.
Publicado: (2018)

Systems modeling of white matter microstructural abnormalities in Alzheimer's disease
por: Horgusluoglu-Moloch, Emrin, et al.
Publicado: (2020)

Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer’s disease
por: Meng, Xianglian, et al.
Publicado: (2020)

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease
por: Park, Young Ho, et al.
Publicado: (2020)

Two-dimensional enrichment analysis for mining high-level imaging genetic associations
por: Yao, Xiaohui, et al.
Publicado: (2016)

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
por: Barupal, Dinesh Kumar, et al.
Publicado: (2019)

BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2021)

Correction to: BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease
por: Kim, Jun Pyo, et al.
Publicado: (2022)

Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer’s disease
por: Kim, Dokyoon, et al.
Publicado: (2017)

Immunity gene IFITM3 variant: Relation to cognition and Alzheimer's disease pathology
por: Pyun, Jung‐Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_20c6gu6jto4l42o3qmb5v0d3o0