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Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671875/ https://www.ncbi.nlm.nih.gov/pubmed/37999389 http://dx.doi.org/10.3390/md21110565 |
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author | Kikionis, Stefanos Iliou, Konstantina Karra, Aikaterini G. Polychronis, Georgios Choinopoulos, Ioannis Iatrou, Hermis Eliades, George Kitraki, Efthymia Tseti, Ioulia Zinelis, Spiros Ioannou, Efstathia Roussis, Vassilios |
author_facet | Kikionis, Stefanos Iliou, Konstantina Karra, Aikaterini G. Polychronis, Georgios Choinopoulos, Ioannis Iatrou, Hermis Eliades, George Kitraki, Efthymia Tseti, Ioulia Zinelis, Spiros Ioannou, Efstathia Roussis, Vassilios |
author_sort | Kikionis, Stefanos |
collection | PubMed |
description | Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier preventing epithelial infiltration and providing adequate time and space for PDL cells and osteoblasts to proliferate into the affected area. Electrospun nanofibrous scaffolds, simulating the natural architecture of the extracellular matrix (ECM), have attracted increasing attention in periodontal tissue engineering. Carrageenans are ideal candidates for the development of novel nanofibrous GTR/GBR membranes, since previous studies have highlighted the potential of carrageenans for bone regeneration by promoting the attachment and proliferation of osteoblasts. Herein, we report the development of bi- and tri-layer nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers for the regeneration of periodontal tissue. The fabricated membranes were morphologically characterized, and their thermal and mechanical properties were determined. Their periodontal tissue regeneration potential was investigated through the evaluation of cell attachment, biocompatibility, and osteogenic differentiation of human PDL cells seeded on the prepared membranes. |
format | Online Article Text |
id | pubmed-10671875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106718752023-10-28 Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration Kikionis, Stefanos Iliou, Konstantina Karra, Aikaterini G. Polychronis, Georgios Choinopoulos, Ioannis Iatrou, Hermis Eliades, George Kitraki, Efthymia Tseti, Ioulia Zinelis, Spiros Ioannou, Efstathia Roussis, Vassilios Mar Drugs Article Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier preventing epithelial infiltration and providing adequate time and space for PDL cells and osteoblasts to proliferate into the affected area. Electrospun nanofibrous scaffolds, simulating the natural architecture of the extracellular matrix (ECM), have attracted increasing attention in periodontal tissue engineering. Carrageenans are ideal candidates for the development of novel nanofibrous GTR/GBR membranes, since previous studies have highlighted the potential of carrageenans for bone regeneration by promoting the attachment and proliferation of osteoblasts. Herein, we report the development of bi- and tri-layer nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers for the regeneration of periodontal tissue. The fabricated membranes were morphologically characterized, and their thermal and mechanical properties were determined. Their periodontal tissue regeneration potential was investigated through the evaluation of cell attachment, biocompatibility, and osteogenic differentiation of human PDL cells seeded on the prepared membranes. MDPI 2023-10-28 /pmc/articles/PMC10671875/ /pubmed/37999389 http://dx.doi.org/10.3390/md21110565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kikionis, Stefanos Iliou, Konstantina Karra, Aikaterini G. Polychronis, Georgios Choinopoulos, Ioannis Iatrou, Hermis Eliades, George Kitraki, Efthymia Tseti, Ioulia Zinelis, Spiros Ioannou, Efstathia Roussis, Vassilios Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title | Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title_full | Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title_fullStr | Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title_full_unstemmed | Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title_short | Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration |
title_sort | development of bi- and tri-layer nanofibrous membranes based on the sulfated polysaccharide carrageenan for periodontal tissue regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671875/ https://www.ncbi.nlm.nih.gov/pubmed/37999389 http://dx.doi.org/10.3390/md21110565 |
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