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Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration

Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone...

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Autores principales: Kikionis, Stefanos, Iliou, Konstantina, Karra, Aikaterini G., Polychronis, Georgios, Choinopoulos, Ioannis, Iatrou, Hermis, Eliades, George, Kitraki, Efthymia, Tseti, Ioulia, Zinelis, Spiros, Ioannou, Efstathia, Roussis, Vassilios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671875/
https://www.ncbi.nlm.nih.gov/pubmed/37999389
http://dx.doi.org/10.3390/md21110565
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author Kikionis, Stefanos
Iliou, Konstantina
Karra, Aikaterini G.
Polychronis, Georgios
Choinopoulos, Ioannis
Iatrou, Hermis
Eliades, George
Kitraki, Efthymia
Tseti, Ioulia
Zinelis, Spiros
Ioannou, Efstathia
Roussis, Vassilios
author_facet Kikionis, Stefanos
Iliou, Konstantina
Karra, Aikaterini G.
Polychronis, Georgios
Choinopoulos, Ioannis
Iatrou, Hermis
Eliades, George
Kitraki, Efthymia
Tseti, Ioulia
Zinelis, Spiros
Ioannou, Efstathia
Roussis, Vassilios
author_sort Kikionis, Stefanos
collection PubMed
description Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier preventing epithelial infiltration and providing adequate time and space for PDL cells and osteoblasts to proliferate into the affected area. Electrospun nanofibrous scaffolds, simulating the natural architecture of the extracellular matrix (ECM), have attracted increasing attention in periodontal tissue engineering. Carrageenans are ideal candidates for the development of novel nanofibrous GTR/GBR membranes, since previous studies have highlighted the potential of carrageenans for bone regeneration by promoting the attachment and proliferation of osteoblasts. Herein, we report the development of bi- and tri-layer nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers for the regeneration of periodontal tissue. The fabricated membranes were morphologically characterized, and their thermal and mechanical properties were determined. Their periodontal tissue regeneration potential was investigated through the evaluation of cell attachment, biocompatibility, and osteogenic differentiation of human PDL cells seeded on the prepared membranes.
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spelling pubmed-106718752023-10-28 Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration Kikionis, Stefanos Iliou, Konstantina Karra, Aikaterini G. Polychronis, Georgios Choinopoulos, Ioannis Iatrou, Hermis Eliades, George Kitraki, Efthymia Tseti, Ioulia Zinelis, Spiros Ioannou, Efstathia Roussis, Vassilios Mar Drugs Article Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier preventing epithelial infiltration and providing adequate time and space for PDL cells and osteoblasts to proliferate into the affected area. Electrospun nanofibrous scaffolds, simulating the natural architecture of the extracellular matrix (ECM), have attracted increasing attention in periodontal tissue engineering. Carrageenans are ideal candidates for the development of novel nanofibrous GTR/GBR membranes, since previous studies have highlighted the potential of carrageenans for bone regeneration by promoting the attachment and proliferation of osteoblasts. Herein, we report the development of bi- and tri-layer nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers for the regeneration of periodontal tissue. The fabricated membranes were morphologically characterized, and their thermal and mechanical properties were determined. Their periodontal tissue regeneration potential was investigated through the evaluation of cell attachment, biocompatibility, and osteogenic differentiation of human PDL cells seeded on the prepared membranes. MDPI 2023-10-28 /pmc/articles/PMC10671875/ /pubmed/37999389 http://dx.doi.org/10.3390/md21110565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kikionis, Stefanos
Iliou, Konstantina
Karra, Aikaterini G.
Polychronis, Georgios
Choinopoulos, Ioannis
Iatrou, Hermis
Eliades, George
Kitraki, Efthymia
Tseti, Ioulia
Zinelis, Spiros
Ioannou, Efstathia
Roussis, Vassilios
Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title_full Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title_fullStr Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title_full_unstemmed Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title_short Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration
title_sort development of bi- and tri-layer nanofibrous membranes based on the sulfated polysaccharide carrageenan for periodontal tissue regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671875/
https://www.ncbi.nlm.nih.gov/pubmed/37999389
http://dx.doi.org/10.3390/md21110565
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