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Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties

Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution...

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Autores principales: He, Jiayu, Liu, Yuandong, Zeng, Xiaofeng, Tong, Yan, Liu, Run, Wang, Kan, Shangguan, Xiangdong, Qiu, Guanzhou, Sipaut, Coswald Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671902/
https://www.ncbi.nlm.nih.gov/pubmed/37998121
http://dx.doi.org/10.3390/jfb14110552
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author He, Jiayu
Liu, Yuandong
Zeng, Xiaofeng
Tong, Yan
Liu, Run
Wang, Kan
Shangguan, Xiangdong
Qiu, Guanzhou
Sipaut, Coswald Stephen
author_facet He, Jiayu
Liu, Yuandong
Zeng, Xiaofeng
Tong, Yan
Liu, Run
Wang, Kan
Shangguan, Xiangdong
Qiu, Guanzhou
Sipaut, Coswald Stephen
author_sort He, Jiayu
collection PubMed
description Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave-sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants.
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spelling pubmed-106719022023-11-17 Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties He, Jiayu Liu, Yuandong Zeng, Xiaofeng Tong, Yan Liu, Run Wang, Kan Shangguan, Xiangdong Qiu, Guanzhou Sipaut, Coswald Stephen J Funct Biomater Article Silicon nitride is a bioceramic with great potential, and multiple studies have demonstrated its biocompatibility and antibacterial properties. In this study, silicon nitride was prepared by a microwave sintering technique that was different from common production methods. SEM and pore distribution analysis revealed the microstructure of microwave-sintered silicon nitride with obvious pores. Mechanical performance analysis shows that microwave sintering can improve the mechanical properties of silicon nitride. The CCK-8 method was used to demonstrate that microwave-sintered silicon nitride has no cytotoxicity and good cytocompatibility. From SEM and CLSM observations, it was observed that there was good adhesion and cross-linking of cells during microwave-sintered silicon nitride, and the morphology of the cytoskeleton was good. Microwave-sintered silicon nitride has been proven to be non-cytotoxic. In addition, the antibacterial ability of microwave-sintered silicon nitride against Staphylococcus aureus and Escherichia coli was tested, proving that it has a good antibacterial ability similar to the silicon nitride prepared by commonly used processes. Compared with silicon nitride prepared by gas pressure sintering technology, microwave-sintered silicon nitride has excellent performance in mechanical properties, cell compatibility, and antibacterial properties. This indicates its enormous potential as a substitute material for manufacturing bone implants. MDPI 2023-11-17 /pmc/articles/PMC10671902/ /pubmed/37998121 http://dx.doi.org/10.3390/jfb14110552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Jiayu
Liu, Yuandong
Zeng, Xiaofeng
Tong, Yan
Liu, Run
Wang, Kan
Shangguan, Xiangdong
Qiu, Guanzhou
Sipaut, Coswald Stephen
Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title_full Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title_fullStr Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title_full_unstemmed Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title_short Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties
title_sort silicon nitride bioceramics sintered by microwave exhibit excellent mechanical properties, cytocompatibility in vitro, and anti-bacterial properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671902/
https://www.ncbi.nlm.nih.gov/pubmed/37998121
http://dx.doi.org/10.3390/jfb14110552
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