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The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil

Objective: Modifications in the severity and clinical expression of Behçet’s disease (BD) have been described in some areas that are considered endemic for the disease. This study aims to evaluate the chronological changes in epidemiology and clinical characteristics of BD patients in a referral cen...

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Autores principales: Hirata, Lilian T., Teixeira, Carlos Eduardo G., Magalhaes, Eduardo P., Del Rio, Ana Paula T., Coimbra, Ibsen Bellini, Sachetto, Zoraida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671945/
https://www.ncbi.nlm.nih.gov/pubmed/38002622
http://dx.doi.org/10.3390/jcm12227008
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author Hirata, Lilian T.
Teixeira, Carlos Eduardo G.
Magalhaes, Eduardo P.
Del Rio, Ana Paula T.
Coimbra, Ibsen Bellini
Sachetto, Zoraida
author_facet Hirata, Lilian T.
Teixeira, Carlos Eduardo G.
Magalhaes, Eduardo P.
Del Rio, Ana Paula T.
Coimbra, Ibsen Bellini
Sachetto, Zoraida
author_sort Hirata, Lilian T.
collection PubMed
description Objective: Modifications in the severity and clinical expression of Behçet’s disease (BD) have been described in some areas that are considered endemic for the disease. This study aims to evaluate the chronological changes in epidemiology and clinical characteristics of BD patients in a referral center in Brazil, which is considered a non-endemic area for the disease. Methods: A descriptive and cross-sectional study involving BD patients divided into two groups: group 1 patients were diagnosed and followed between 1988 and 2010, and group 2 were diagnosed and followed between 2011 and 2022. Results: No significant differences were found regarding gender and age at onset of symptoms between groups. We found a significant decrease in the frequency of bilateral ocular involvement, posterior uveitis, and retinal vasculitis. Conclusion: The demographic dates of this group of Brazilian BD patients remained similar over the last decade. Our study supports the notion that BD is becoming lighter in some regions. BD is a severe blinding disorder, and we found a lower frequency of ocular involvement over time. These findings may be attributed to a higher level of education of patients and a growing awareness of the disease. Newer immunomodulating and biologic agents may offer an improved prognosis in patients with BD with severe manifestations.
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spelling pubmed-106719452023-11-09 The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil Hirata, Lilian T. Teixeira, Carlos Eduardo G. Magalhaes, Eduardo P. Del Rio, Ana Paula T. Coimbra, Ibsen Bellini Sachetto, Zoraida J Clin Med Brief Report Objective: Modifications in the severity and clinical expression of Behçet’s disease (BD) have been described in some areas that are considered endemic for the disease. This study aims to evaluate the chronological changes in epidemiology and clinical characteristics of BD patients in a referral center in Brazil, which is considered a non-endemic area for the disease. Methods: A descriptive and cross-sectional study involving BD patients divided into two groups: group 1 patients were diagnosed and followed between 1988 and 2010, and group 2 were diagnosed and followed between 2011 and 2022. Results: No significant differences were found regarding gender and age at onset of symptoms between groups. We found a significant decrease in the frequency of bilateral ocular involvement, posterior uveitis, and retinal vasculitis. Conclusion: The demographic dates of this group of Brazilian BD patients remained similar over the last decade. Our study supports the notion that BD is becoming lighter in some regions. BD is a severe blinding disorder, and we found a lower frequency of ocular involvement over time. These findings may be attributed to a higher level of education of patients and a growing awareness of the disease. Newer immunomodulating and biologic agents may offer an improved prognosis in patients with BD with severe manifestations. MDPI 2023-11-09 /pmc/articles/PMC10671945/ /pubmed/38002622 http://dx.doi.org/10.3390/jcm12227008 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Hirata, Lilian T.
Teixeira, Carlos Eduardo G.
Magalhaes, Eduardo P.
Del Rio, Ana Paula T.
Coimbra, Ibsen Bellini
Sachetto, Zoraida
The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title_full The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title_fullStr The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title_full_unstemmed The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title_short The Influence of Time on the Epidemiology and Clinical Manifestations of Behçet’s Disease in Brazil
title_sort influence of time on the epidemiology and clinical manifestations of behçet’s disease in brazil
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671945/
https://www.ncbi.nlm.nih.gov/pubmed/38002622
http://dx.doi.org/10.3390/jcm12227008
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