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Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

Background: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function. Methods: Thirty-one patients were investigated over a mean follow-up of 90 days (22–527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis...

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Autores principales: Törzsök, Peter, Oswald, David, Steiner, Christopher, Abenhardt, Michael, Ramesmayer, Christian, Milinovic, Ljiljana, Plank, Bethseba, Tischleritsch, Zoe, Lusuardi, Lukas, Deininger, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672023/
https://www.ncbi.nlm.nih.gov/pubmed/38002711
http://dx.doi.org/10.3390/jcm12227099
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author Törzsök, Peter
Oswald, David
Steiner, Christopher
Abenhardt, Michael
Ramesmayer, Christian
Milinovic, Ljiljana
Plank, Bethseba
Tischleritsch, Zoe
Lusuardi, Lukas
Deininger, Susanne
author_facet Törzsök, Peter
Oswald, David
Steiner, Christopher
Abenhardt, Michael
Ramesmayer, Christian
Milinovic, Ljiljana
Plank, Bethseba
Tischleritsch, Zoe
Lusuardi, Lukas
Deininger, Susanne
author_sort Törzsök, Peter
collection PubMed
description Background: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function. Methods: Thirty-one patients were investigated over a mean follow-up of 90 days (22–527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection. Results: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone. Conclusion: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.
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spelling pubmed-106720232023-11-15 Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function Törzsök, Peter Oswald, David Steiner, Christopher Abenhardt, Michael Ramesmayer, Christian Milinovic, Ljiljana Plank, Bethseba Tischleritsch, Zoe Lusuardi, Lukas Deininger, Susanne J Clin Med Article Background: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function. Methods: Thirty-one patients were investigated over a mean follow-up of 90 days (22–527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection. Results: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone. Conclusion: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility. MDPI 2023-11-15 /pmc/articles/PMC10672023/ /pubmed/38002711 http://dx.doi.org/10.3390/jcm12227099 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Törzsök, Peter
Oswald, David
Steiner, Christopher
Abenhardt, Michael
Ramesmayer, Christian
Milinovic, Ljiljana
Plank, Bethseba
Tischleritsch, Zoe
Lusuardi, Lukas
Deininger, Susanne
Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title_full Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title_fullStr Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title_full_unstemmed Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title_short Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function
title_sort effects of covid-19 infection on spermatogenesis, oxidative stress and erectile function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672023/
https://www.ncbi.nlm.nih.gov/pubmed/38002711
http://dx.doi.org/10.3390/jcm12227099
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