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Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery

Background: Cytoreductive surgery (CRS) is a complex procedure with a high incidence of perioperative complications. Elevated lactacidaemia levels have been associated with complications and perioperative morbidity and mortality. This study aims to analyse the intraoperative variables of patients un...

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Autores principales: Soriano Hervás, Marta, Robles-Hernández, Daniel, Serra, Anna, Játiva-Porcar, Rosa, Gómez Quiles, Luis, Maiocchi, Karina, Llorca, Sara, Climent, María Teresa, Llueca, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672096/
https://www.ncbi.nlm.nih.gov/pubmed/38003855
http://dx.doi.org/10.3390/jpm13111540
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author Soriano Hervás, Marta
Robles-Hernández, Daniel
Serra, Anna
Játiva-Porcar, Rosa
Gómez Quiles, Luis
Maiocchi, Karina
Llorca, Sara
Climent, María Teresa
Llueca, Antoni
author_facet Soriano Hervás, Marta
Robles-Hernández, Daniel
Serra, Anna
Játiva-Porcar, Rosa
Gómez Quiles, Luis
Maiocchi, Karina
Llorca, Sara
Climent, María Teresa
Llueca, Antoni
author_sort Soriano Hervás, Marta
collection PubMed
description Background: Cytoreductive surgery (CRS) is a complex procedure with a high incidence of perioperative complications. Elevated lactacidaemia levels have been associated with complications and perioperative morbidity and mortality. This study aims to analyse the intraoperative variables of patients undergoing CRS and their relationship with lactacidaemia levels. Methods: This retrospective, observational study included 51 patients with peritoneal carcinomatosis who underwent CRS between 2014 and 2016 at the Abdomino-Pelvic Oncological Surgery Reference Unit (URCOAP) of the General University Hospital of Castellón (HGUCS). The main variable of interest was the level of lactic acid at the end of surgery. Intraoperative variables, including preoperative haemoglobin, duration of surgery, intraoperative bleeding, fluid therapy administered, administration of blood products, and intraoperative peritoneal cancer index (PCI), were analysed. Results: Positive correlations were found between lactic acid levels and PCI, duration of intervention, fluid therapy, intraoperative bleeding, and transfusion of blood products. Additionally, a negative correlation was observed between haemoglobin levels and lactic acid levels. Notably, the strongest correlations were found with operative PCI (ρ = 0.532; p-value < 0.001) and duration of surgery (ρ = 0.518; p-value < 0.001). Conclusions: PCI and duration of surgery are decisive variables in determining the prognosis of patients undergoing debulking surgery. This study suggests that, for each minute of surgery, lactic acid levels increase by 0.005 mmol/L, and for each unit increase in PCI, lactic acid levels increase by 0.060 mmol/L.
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spelling pubmed-106720962023-10-26 Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery Soriano Hervás, Marta Robles-Hernández, Daniel Serra, Anna Játiva-Porcar, Rosa Gómez Quiles, Luis Maiocchi, Karina Llorca, Sara Climent, María Teresa Llueca, Antoni J Pers Med Article Background: Cytoreductive surgery (CRS) is a complex procedure with a high incidence of perioperative complications. Elevated lactacidaemia levels have been associated with complications and perioperative morbidity and mortality. This study aims to analyse the intraoperative variables of patients undergoing CRS and their relationship with lactacidaemia levels. Methods: This retrospective, observational study included 51 patients with peritoneal carcinomatosis who underwent CRS between 2014 and 2016 at the Abdomino-Pelvic Oncological Surgery Reference Unit (URCOAP) of the General University Hospital of Castellón (HGUCS). The main variable of interest was the level of lactic acid at the end of surgery. Intraoperative variables, including preoperative haemoglobin, duration of surgery, intraoperative bleeding, fluid therapy administered, administration of blood products, and intraoperative peritoneal cancer index (PCI), were analysed. Results: Positive correlations were found between lactic acid levels and PCI, duration of intervention, fluid therapy, intraoperative bleeding, and transfusion of blood products. Additionally, a negative correlation was observed between haemoglobin levels and lactic acid levels. Notably, the strongest correlations were found with operative PCI (ρ = 0.532; p-value < 0.001) and duration of surgery (ρ = 0.518; p-value < 0.001). Conclusions: PCI and duration of surgery are decisive variables in determining the prognosis of patients undergoing debulking surgery. This study suggests that, for each minute of surgery, lactic acid levels increase by 0.005 mmol/L, and for each unit increase in PCI, lactic acid levels increase by 0.060 mmol/L. MDPI 2023-10-26 /pmc/articles/PMC10672096/ /pubmed/38003855 http://dx.doi.org/10.3390/jpm13111540 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soriano Hervás, Marta
Robles-Hernández, Daniel
Serra, Anna
Játiva-Porcar, Rosa
Gómez Quiles, Luis
Maiocchi, Karina
Llorca, Sara
Climent, María Teresa
Llueca, Antoni
Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title_full Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title_fullStr Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title_full_unstemmed Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title_short Analysis of Intraoperative Variables Responsible for the Increase in Lactic Acid in Patients Undergoing Debulking Surgery
title_sort analysis of intraoperative variables responsible for the increase in lactic acid in patients undergoing debulking surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672096/
https://www.ncbi.nlm.nih.gov/pubmed/38003855
http://dx.doi.org/10.3390/jpm13111540
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