CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue sarcomas with limited treatment options, and new effective therapeutic strategies are desperately needed. We observe antiproliferative potency of genetic depletion of PTPN11 or pharmacological inhibition using the SH...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiawan, Calizo, Ana, Zhang, Lindy, Pino, James C., Lyu, Yang, Pollard, Kai, Zhang, Xiaochun, Larsson, Alex T., Conniff, Eric, Llosa, Nicolas J., Wood, David K., Largaespada, David A., Moody, Susan E., Gosline, Sara J., Hirbe, Angela C., Pratilas, Christine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672174/
https://www.ncbi.nlm.nih.gov/pubmed/38000020
http://dx.doi.org/10.1126/sciadv.adg8876

Ejemplares similares

Ejemplares similares