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Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication

Fabricating helical scaffolds using electrospinning is a common approach for cardiac implantation, aiming to achieve properties similar to native tissue. However, this process requires multiple experimental attempts to select suitable electrospun properties and validate resulting mechanical response...

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Detalles Bibliográficos
Autores principales: Gkouti, Elli, Czekanski, Aleksander, AlAttar, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672181/
https://www.ncbi.nlm.nih.gov/pubmed/38005025
http://dx.doi.org/10.3390/ma16227095
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author Gkouti, Elli
Czekanski, Aleksander
AlAttar, Ahmed
author_facet Gkouti, Elli
Czekanski, Aleksander
AlAttar, Ahmed
author_sort Gkouti, Elli
collection PubMed
description Fabricating helical scaffolds using electrospinning is a common approach for cardiac implantation, aiming to achieve properties similar to native tissue. However, this process requires multiple experimental attempts to select suitable electrospun properties and validate resulting mechanical responses. To overcome the time and cost constraints associated with this iterative procedure, Finite Element Analysis (FEA) can be applied using stable hyperelastic and viscoelastic models that describe the response of electrospun scaffolds under different conditions. In this study, we aim to create accurate simulations of the viscoelastic behavior of electrospun helical scaffolds. We fabricated helical fibers from Poly (3-caprolactone) (PCL) using the electrospinning process to achieve this. The electrospun samples were subjected to uniaxial deformation, and their response was modelled using existing hyperelastic and stress relaxation models. The simulations were built on experimental data for specific deformation speed and maximum strain conditions. The FEM results were evaluated by accounting for the stress-softening phenomenon, which significantly impacted the models. The electrospun scaffolds’ predictions were performed in other than the initial experimental conditions to verify our simulations’ accuracy and reliability.
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spelling pubmed-106721812023-11-09 Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication Gkouti, Elli Czekanski, Aleksander AlAttar, Ahmed Materials (Basel) Article Fabricating helical scaffolds using electrospinning is a common approach for cardiac implantation, aiming to achieve properties similar to native tissue. However, this process requires multiple experimental attempts to select suitable electrospun properties and validate resulting mechanical responses. To overcome the time and cost constraints associated with this iterative procedure, Finite Element Analysis (FEA) can be applied using stable hyperelastic and viscoelastic models that describe the response of electrospun scaffolds under different conditions. In this study, we aim to create accurate simulations of the viscoelastic behavior of electrospun helical scaffolds. We fabricated helical fibers from Poly (3-caprolactone) (PCL) using the electrospinning process to achieve this. The electrospun samples were subjected to uniaxial deformation, and their response was modelled using existing hyperelastic and stress relaxation models. The simulations were built on experimental data for specific deformation speed and maximum strain conditions. The FEM results were evaluated by accounting for the stress-softening phenomenon, which significantly impacted the models. The electrospun scaffolds’ predictions were performed in other than the initial experimental conditions to verify our simulations’ accuracy and reliability. MDPI 2023-11-09 /pmc/articles/PMC10672181/ /pubmed/38005025 http://dx.doi.org/10.3390/ma16227095 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gkouti, Elli
Czekanski, Aleksander
AlAttar, Ahmed
Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title_full Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title_fullStr Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title_full_unstemmed Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title_short Simulating and Predicting the Mechanical Behavior of Electrospun Scaffolds for Cardiac Patches Fabrication
title_sort simulating and predicting the mechanical behavior of electrospun scaffolds for cardiac patches fabrication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672181/
https://www.ncbi.nlm.nih.gov/pubmed/38005025
http://dx.doi.org/10.3390/ma16227095
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