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Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions

In the advent of an increasingly aging population and due to the popularity of electronic devices, ocular conditions have become more prevalent. In the world of medicine, accomplishing eye medication administration has always been a difficult task. Despite the fact that there are many commercial eye...

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Autores principales: Ioniță, Mariana, Vlăsceanu, George Mihail, Toader, Alin Georgian, Manole, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672201/
https://www.ncbi.nlm.nih.gov/pubmed/38003886
http://dx.doi.org/10.3390/jpm13111571
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author Ioniță, Mariana
Vlăsceanu, George Mihail
Toader, Alin Georgian
Manole, Marius
author_facet Ioniță, Mariana
Vlăsceanu, George Mihail
Toader, Alin Georgian
Manole, Marius
author_sort Ioniță, Mariana
collection PubMed
description In the advent of an increasingly aging population and due to the popularity of electronic devices, ocular conditions have become more prevalent. In the world of medicine, accomplishing eye medication administration has always been a difficult task. Despite the fact that there are many commercial eye drops, most of them have important limitations, due to quick clearance mechanisms and ocular barrers. One solution with tremendous potential is the contact lens used as a medication delivery vehicle to bypass this constraint. Therapeutic contact lenses for ocular medication delivery have attracted a lot of attention because they have the potential to improve ocular bioavailability and patient compliance, both with minimal side effects. However, it is essential not to compromise essential features such as water content, optical transparency, and modulus to attain positive in vitro and in vivo outcomes with respect to a sustained drug delivery profile from impregnated contact lenses. Aside from difficulties like drug stability and burst release, the changing of lens physico-chemical features caused by therapeutic or non-therapeutic components can limit the commercialization potential of pharmaceutical-loaded lenses. Research has progressed towards bioinspired techniques and smart materials, to improve the efficacy of drug-eluting contact lenses. The bioinspired method uses polymeric materials, and a specialized molecule-recognition technique called molecular imprinting or a stimuli–responsive system to improve biocompatibility and support the drug delivery efficacy of drug-eluting contact lenses. This review encompasses strategies of material design, lens manufacturing and drug impregnation under the current auspices of ophthalmic therapies and projects an outlook onto future opportunities in the field of eye condition management by means of an active principle-eluting contact lens.
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spelling pubmed-106722012023-11-03 Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions Ioniță, Mariana Vlăsceanu, George Mihail Toader, Alin Georgian Manole, Marius J Pers Med Review In the advent of an increasingly aging population and due to the popularity of electronic devices, ocular conditions have become more prevalent. In the world of medicine, accomplishing eye medication administration has always been a difficult task. Despite the fact that there are many commercial eye drops, most of them have important limitations, due to quick clearance mechanisms and ocular barrers. One solution with tremendous potential is the contact lens used as a medication delivery vehicle to bypass this constraint. Therapeutic contact lenses for ocular medication delivery have attracted a lot of attention because they have the potential to improve ocular bioavailability and patient compliance, both with minimal side effects. However, it is essential not to compromise essential features such as water content, optical transparency, and modulus to attain positive in vitro and in vivo outcomes with respect to a sustained drug delivery profile from impregnated contact lenses. Aside from difficulties like drug stability and burst release, the changing of lens physico-chemical features caused by therapeutic or non-therapeutic components can limit the commercialization potential of pharmaceutical-loaded lenses. Research has progressed towards bioinspired techniques and smart materials, to improve the efficacy of drug-eluting contact lenses. The bioinspired method uses polymeric materials, and a specialized molecule-recognition technique called molecular imprinting or a stimuli–responsive system to improve biocompatibility and support the drug delivery efficacy of drug-eluting contact lenses. This review encompasses strategies of material design, lens manufacturing and drug impregnation under the current auspices of ophthalmic therapies and projects an outlook onto future opportunities in the field of eye condition management by means of an active principle-eluting contact lens. MDPI 2023-11-03 /pmc/articles/PMC10672201/ /pubmed/38003886 http://dx.doi.org/10.3390/jpm13111571 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ioniță, Mariana
Vlăsceanu, George Mihail
Toader, Alin Georgian
Manole, Marius
Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title_full Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title_fullStr Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title_full_unstemmed Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title_short Advances in Therapeutic Contact Lenses for the Management of Different Ocular Conditions
title_sort advances in therapeutic contact lenses for the management of different ocular conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672201/
https://www.ncbi.nlm.nih.gov/pubmed/38003886
http://dx.doi.org/10.3390/jpm13111571
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