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Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin

The aim of this study is to assess and analyze the intratubular penetration of the intracanal medications nitrofurantoin (Nit), triple antibiotic paste (TAP), and calcium hydroxide (CH). Sixty freshly extracted single-rooted teeth were acquired and decoronated to a standard length of 15 mm. To prepa...

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Autores principales: Khanvilkar, Unmesh, Pawar, Sanika, Bandekar, Siddhesh, Dhok, Vaishnavi, Arora, Suraj, Pawar, Ajinkya M., Pagnoni, Francesco, Reda, Rodolfo, Testarelli, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672212/
https://www.ncbi.nlm.nih.gov/pubmed/38003869
http://dx.doi.org/10.3390/jpm13111554
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author Khanvilkar, Unmesh
Pawar, Sanika
Bandekar, Siddhesh
Dhok, Vaishnavi
Arora, Suraj
Pawar, Ajinkya M.
Pagnoni, Francesco
Reda, Rodolfo
Testarelli, Luca
author_facet Khanvilkar, Unmesh
Pawar, Sanika
Bandekar, Siddhesh
Dhok, Vaishnavi
Arora, Suraj
Pawar, Ajinkya M.
Pagnoni, Francesco
Reda, Rodolfo
Testarelli, Luca
author_sort Khanvilkar, Unmesh
collection PubMed
description The aim of this study is to assess and analyze the intratubular penetration of the intracanal medications nitrofurantoin (Nit), triple antibiotic paste (TAP), and calcium hydroxide (CH). Sixty freshly extracted single-rooted teeth were acquired and decoronated to a standard length of 15 mm. To prepare specimens up to size F3, rotary ProTaper instrumentation was employed. The prepared teeth were divided into three groups, each of which received one of the tested intracanal medicaments: Group I (calcium hydroxide), Group II (triple antibiotic paste), and Group III (nitrofurantoin). Using a size #30 Lentulo spiral, a freshly prepared therapeutic paste was placed into the canals, and the intracanal medicaments were allowed to set in the incubator at 100% humidity. The samples were subsequently sliced perpendicularly to their long axis using a precision saw and assessed under a scanning electron microscope to assess the depth of penetration of intracanal medicaments at the coronal, middle, and apical portions of the root canal dentin. The data were analyzed using one-way ANOVA and Tukey’s post hoc test. The statistical analysis revealed a significant difference between the experimental groups in the quantity and depth of sealer penetration (p < 0.05). In particular, as compared to the Nit group, both the CH and TAP groups had significantly smaller penetration areas (p < 0.05). In conclusion, this ongoing investigation indicates that nitrofurantoin penetrated dentinal tubules better than calcium hydroxide or triple antibiotic paste.
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spelling pubmed-106722122023-10-30 Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin Khanvilkar, Unmesh Pawar, Sanika Bandekar, Siddhesh Dhok, Vaishnavi Arora, Suraj Pawar, Ajinkya M. Pagnoni, Francesco Reda, Rodolfo Testarelli, Luca J Pers Med Article The aim of this study is to assess and analyze the intratubular penetration of the intracanal medications nitrofurantoin (Nit), triple antibiotic paste (TAP), and calcium hydroxide (CH). Sixty freshly extracted single-rooted teeth were acquired and decoronated to a standard length of 15 mm. To prepare specimens up to size F3, rotary ProTaper instrumentation was employed. The prepared teeth were divided into three groups, each of which received one of the tested intracanal medicaments: Group I (calcium hydroxide), Group II (triple antibiotic paste), and Group III (nitrofurantoin). Using a size #30 Lentulo spiral, a freshly prepared therapeutic paste was placed into the canals, and the intracanal medicaments were allowed to set in the incubator at 100% humidity. The samples were subsequently sliced perpendicularly to their long axis using a precision saw and assessed under a scanning electron microscope to assess the depth of penetration of intracanal medicaments at the coronal, middle, and apical portions of the root canal dentin. The data were analyzed using one-way ANOVA and Tukey’s post hoc test. The statistical analysis revealed a significant difference between the experimental groups in the quantity and depth of sealer penetration (p < 0.05). In particular, as compared to the Nit group, both the CH and TAP groups had significantly smaller penetration areas (p < 0.05). In conclusion, this ongoing investigation indicates that nitrofurantoin penetrated dentinal tubules better than calcium hydroxide or triple antibiotic paste. MDPI 2023-10-30 /pmc/articles/PMC10672212/ /pubmed/38003869 http://dx.doi.org/10.3390/jpm13111554 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khanvilkar, Unmesh
Pawar, Sanika
Bandekar, Siddhesh
Dhok, Vaishnavi
Arora, Suraj
Pawar, Ajinkya M.
Pagnoni, Francesco
Reda, Rodolfo
Testarelli, Luca
Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title_full Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title_fullStr Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title_full_unstemmed Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title_short Scanning Electron Microscopy Analysis of the Intratubular Radicular Dentin Penetration of Calcium Hydroxide, Triple Antibiotic Paste, and Nitrofurantoin
title_sort scanning electron microscopy analysis of the intratubular radicular dentin penetration of calcium hydroxide, triple antibiotic paste, and nitrofurantoin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672212/
https://www.ncbi.nlm.nih.gov/pubmed/38003869
http://dx.doi.org/10.3390/jpm13111554
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