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Vasopressin in Sepsis and Other Shock States: State of the Art
This review of the use of vasopressin aims to be comprehensive and highly practical, based on the available scientific evidence and our extensive clinical experience with the drug. It summarizes controversies about vasopressin use in septic shock and other vasodilatory states. Vasopressin is a natur...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672256/ https://www.ncbi.nlm.nih.gov/pubmed/38003863 http://dx.doi.org/10.3390/jpm13111548 |
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author | García-Álvarez, Raquel Arboleda-Salazar, Rafael |
author_facet | García-Álvarez, Raquel Arboleda-Salazar, Rafael |
author_sort | García-Álvarez, Raquel |
collection | PubMed |
description | This review of the use of vasopressin aims to be comprehensive and highly practical, based on the available scientific evidence and our extensive clinical experience with the drug. It summarizes controversies about vasopressin use in septic shock and other vasodilatory states. Vasopressin is a natural hormone with powerful vasoconstrictive effects and is responsible for the regulation of plasma osmolality by maintaining fluid homeostasis. Septic shock is defined by the need for vasopressors to correct hypotension and lactic acidosis secondary to infection, with a high mortality rate. The Surviving Sepsis Campaign guidelines recommend vasopressin as a second-line vasopressor, added to norepinephrine. However, these guidelines do not address specific debates surrounding the use of vasopressin in real-world clinical practice. |
format | Online Article Text |
id | pubmed-10672256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106722562023-10-29 Vasopressin in Sepsis and Other Shock States: State of the Art García-Álvarez, Raquel Arboleda-Salazar, Rafael J Pers Med Review This review of the use of vasopressin aims to be comprehensive and highly practical, based on the available scientific evidence and our extensive clinical experience with the drug. It summarizes controversies about vasopressin use in septic shock and other vasodilatory states. Vasopressin is a natural hormone with powerful vasoconstrictive effects and is responsible for the regulation of plasma osmolality by maintaining fluid homeostasis. Septic shock is defined by the need for vasopressors to correct hypotension and lactic acidosis secondary to infection, with a high mortality rate. The Surviving Sepsis Campaign guidelines recommend vasopressin as a second-line vasopressor, added to norepinephrine. However, these guidelines do not address specific debates surrounding the use of vasopressin in real-world clinical practice. MDPI 2023-10-29 /pmc/articles/PMC10672256/ /pubmed/38003863 http://dx.doi.org/10.3390/jpm13111548 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review García-Álvarez, Raquel Arboleda-Salazar, Rafael Vasopressin in Sepsis and Other Shock States: State of the Art |
title | Vasopressin in Sepsis and Other Shock States: State of the Art |
title_full | Vasopressin in Sepsis and Other Shock States: State of the Art |
title_fullStr | Vasopressin in Sepsis and Other Shock States: State of the Art |
title_full_unstemmed | Vasopressin in Sepsis and Other Shock States: State of the Art |
title_short | Vasopressin in Sepsis and Other Shock States: State of the Art |
title_sort | vasopressin in sepsis and other shock states: state of the art |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672256/ https://www.ncbi.nlm.nih.gov/pubmed/38003863 http://dx.doi.org/10.3390/jpm13111548 |
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