Cargando…

Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques

Many retinal diseases and imaging findings have pathophysiologic underpinnings in the function of the cardiovascular system. Myriad retinal conditions, new imaging biomarkers, and novel image analysis techniques have been investigated for their association with future cardiovascular risk or utility...

Descripción completa

Detalles Bibliográficos
Autores principales: Colcombe, Joseph, Mundae, Rusdeep, Kaiser, Alexis, Bijon, Jacques, Modi, Yasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672409/
https://www.ncbi.nlm.nih.gov/pubmed/38003879
http://dx.doi.org/10.3390/jpm13111564
_version_ 1785140384474595328
author Colcombe, Joseph
Mundae, Rusdeep
Kaiser, Alexis
Bijon, Jacques
Modi, Yasha
author_facet Colcombe, Joseph
Mundae, Rusdeep
Kaiser, Alexis
Bijon, Jacques
Modi, Yasha
author_sort Colcombe, Joseph
collection PubMed
description Many retinal diseases and imaging findings have pathophysiologic underpinnings in the function of the cardiovascular system. Myriad retinal conditions, new imaging biomarkers, and novel image analysis techniques have been investigated for their association with future cardiovascular risk or utility in cardiovascular risk prognostication. An intensive literature search was performed to identify relevant articles indexed in PubMed, Scopus, and Google Scholar for a targeted narrative review. This review investigates the literature on specific retinal disease states, such as retinal arterial and venous occlusions and cotton wool spots, that portend significantly increased risk of future cardiovascular events, such as stroke or myocardial infarction, and the implications for personalized patient counseling. Furthermore, conditions diagnosed primarily through retinal bioimaging, such as paracentral acute middle maculopathy and the newly discovered entity known as a retinal ischemic perivascular lesion, may be associated with future incident cardiovascular morbidity and are also discussed. As ever-more-sophisticated imaging biomarkers and analysis techniques are developed, the review concludes with a focused analysis of optical coherence tomography and optical coherence tomography angiography biomarkers under investigation for potential value in prognostication and personalized therapy in cardiovascular disease.
format Online
Article
Text
id pubmed-10672409
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106724092023-10-31 Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques Colcombe, Joseph Mundae, Rusdeep Kaiser, Alexis Bijon, Jacques Modi, Yasha J Pers Med Review Many retinal diseases and imaging findings have pathophysiologic underpinnings in the function of the cardiovascular system. Myriad retinal conditions, new imaging biomarkers, and novel image analysis techniques have been investigated for their association with future cardiovascular risk or utility in cardiovascular risk prognostication. An intensive literature search was performed to identify relevant articles indexed in PubMed, Scopus, and Google Scholar for a targeted narrative review. This review investigates the literature on specific retinal disease states, such as retinal arterial and venous occlusions and cotton wool spots, that portend significantly increased risk of future cardiovascular events, such as stroke or myocardial infarction, and the implications for personalized patient counseling. Furthermore, conditions diagnosed primarily through retinal bioimaging, such as paracentral acute middle maculopathy and the newly discovered entity known as a retinal ischemic perivascular lesion, may be associated with future incident cardiovascular morbidity and are also discussed. As ever-more-sophisticated imaging biomarkers and analysis techniques are developed, the review concludes with a focused analysis of optical coherence tomography and optical coherence tomography angiography biomarkers under investigation for potential value in prognostication and personalized therapy in cardiovascular disease. MDPI 2023-10-31 /pmc/articles/PMC10672409/ /pubmed/38003879 http://dx.doi.org/10.3390/jpm13111564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colcombe, Joseph
Mundae, Rusdeep
Kaiser, Alexis
Bijon, Jacques
Modi, Yasha
Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title_full Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title_fullStr Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title_full_unstemmed Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title_short Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques
title_sort retinal findings and cardiovascular risk: prognostic conditions, novel biomarkers, and emerging image analysis techniques
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672409/
https://www.ncbi.nlm.nih.gov/pubmed/38003879
http://dx.doi.org/10.3390/jpm13111564
work_keys_str_mv AT colcombejoseph retinalfindingsandcardiovascularriskprognosticconditionsnovelbiomarkersandemergingimageanalysistechniques
AT mundaerusdeep retinalfindingsandcardiovascularriskprognosticconditionsnovelbiomarkersandemergingimageanalysistechniques
AT kaiseralexis retinalfindingsandcardiovascularriskprognosticconditionsnovelbiomarkersandemergingimageanalysistechniques
AT bijonjacques retinalfindingsandcardiovascularriskprognosticconditionsnovelbiomarkersandemergingimageanalysistechniques
AT modiyasha retinalfindingsandcardiovascularriskprognosticconditionsnovelbiomarkersandemergingimageanalysistechniques