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The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review

Regenerative techniques are increasingly applied in endodontic surgery, but different materials may have varying impacts on soft and hard tissue healing. This systematic review aims to evaluate the effectiveness of autologous platelet concentrates (APCs) in clinical and radiographic healing after en...

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Autores principales: di Lauro, Alessandro Espedito, Valletta, Alessandra, Aliberti, Angelo, Cangiano, Mario, Dolce, Pasquale, Sammartino, Gilberto, Gasparro, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672445/
https://www.ncbi.nlm.nih.gov/pubmed/38005117
http://dx.doi.org/10.3390/ma16227187
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author di Lauro, Alessandro Espedito
Valletta, Alessandra
Aliberti, Angelo
Cangiano, Mario
Dolce, Pasquale
Sammartino, Gilberto
Gasparro, Roberta
author_facet di Lauro, Alessandro Espedito
Valletta, Alessandra
Aliberti, Angelo
Cangiano, Mario
Dolce, Pasquale
Sammartino, Gilberto
Gasparro, Roberta
author_sort di Lauro, Alessandro Espedito
collection PubMed
description Regenerative techniques are increasingly applied in endodontic surgery, but different materials may have varying impacts on soft and hard tissue healing. This systematic review aims to evaluate the effectiveness of autologous platelet concentrates (APCs) in clinical and radiographic healing after endodontic surgery. The data for this systematic review were processed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for improving the reporting of systematic reviews and meta-analyses. A literature search was conducted until October 2023 on PubMed, Scopus, and Cochrane Databases. Randomized controlled trials and controlled clinical trials addressing the use of APCs in patients who presented persistent periapical lesions and needed periapical surgery were included. Dual publications, narrative reviews, systematic reviews, case series, questionnaires, animal studies, case reports, letters to the editor, in vitro studies, and abstracts were excluded. In total, the search resulted in 14 papers. Clinical and radiographical findings were reported, showing that when APCs were used, patients exhibited less pain and swelling and a greater reduction of apical radiolucency after 12 months follow-up on average. However, the moderate/high risk of bias of included studies and their high heterogeneity, do not allow one to draw definitive conclusions on the effectiveness of APC after endodontic surgery.
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spelling pubmed-106724452023-11-16 The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review di Lauro, Alessandro Espedito Valletta, Alessandra Aliberti, Angelo Cangiano, Mario Dolce, Pasquale Sammartino, Gilberto Gasparro, Roberta Materials (Basel) Review Regenerative techniques are increasingly applied in endodontic surgery, but different materials may have varying impacts on soft and hard tissue healing. This systematic review aims to evaluate the effectiveness of autologous platelet concentrates (APCs) in clinical and radiographic healing after endodontic surgery. The data for this systematic review were processed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for improving the reporting of systematic reviews and meta-analyses. A literature search was conducted until October 2023 on PubMed, Scopus, and Cochrane Databases. Randomized controlled trials and controlled clinical trials addressing the use of APCs in patients who presented persistent periapical lesions and needed periapical surgery were included. Dual publications, narrative reviews, systematic reviews, case series, questionnaires, animal studies, case reports, letters to the editor, in vitro studies, and abstracts were excluded. In total, the search resulted in 14 papers. Clinical and radiographical findings were reported, showing that when APCs were used, patients exhibited less pain and swelling and a greater reduction of apical radiolucency after 12 months follow-up on average. However, the moderate/high risk of bias of included studies and their high heterogeneity, do not allow one to draw definitive conclusions on the effectiveness of APC after endodontic surgery. MDPI 2023-11-16 /pmc/articles/PMC10672445/ /pubmed/38005117 http://dx.doi.org/10.3390/ma16227187 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
di Lauro, Alessandro Espedito
Valletta, Alessandra
Aliberti, Angelo
Cangiano, Mario
Dolce, Pasquale
Sammartino, Gilberto
Gasparro, Roberta
The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title_full The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title_fullStr The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title_full_unstemmed The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title_short The Effectiveness of Autologous Platelet Concentrates in the Clinical and Radiographic Healing after Endodontic Surgery: A Systematic Review
title_sort effectiveness of autologous platelet concentrates in the clinical and radiographic healing after endodontic surgery: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672445/
https://www.ncbi.nlm.nih.gov/pubmed/38005117
http://dx.doi.org/10.3390/ma16227187
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