Cargando…

PM(2.5) Exposure-Linked Mitochondrial Dysfunction Negates SB216763-Mediated Cardio-Protection against Myocardial Ischemia–Reperfusion Injury

GSK3β is a promising target for treating various disease conditions, including myocardial ischemia–reperfusion injury (IR). This study investigated the potential of GSK3β as a novel drug for managing IR in rats exposed to PM(2.5) for 1 day and up to 21 days. Female Wistar rats were exposed to PM(2.5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sivakumar, Bhavana, Nadeem, Ahmed, Dar, Mashooq Ahmad, Kurian, Gino A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672572/ https://www.ncbi.nlm.nih.gov/pubmed/38004374 http://dx.doi.org/10.3390/life13112234

Ejemplares similares

PM(2.5)-Induced Cardiac Structural Modifications and Declined Pro-Survival Signalling Pathways Are Responsible for the Inefficiency of GSK-3β Inhibitor in Attenuating Myocardial Ischemia-Reperfusion Injury in Rats
por: Sivakumar, Bhavana, et al.
Publicado: (2023)

Fisetin Attenuates Myocardial Ischemia-Reperfusion Injury by Activating the Reperfusion Injury Salvage Kinase (RISK) Signaling Pathway
por: Shanmugam, Karthi, et al.
Publicado: (2021)

Consequential Impact of Particulate Matter Linked Inter-Fibrillar Mitochondrial Dysfunction in Rat Myocardium Subjected to Ischemia Reperfusion Injury
por: Sivakumar, Bhavana, et al.
Publicado: (2022)

Small-Molecule SB216763-Loaded Microspheres Repair Peripheral Nerve Injury in Small Gap Tubulization
por: Rao, Feng, et al.
Publicado: (2019)

Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons
por: Zhang, Jing, et al.
Publicado: (2020)

Testing Fmr1(KO) Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127
por: Westmark, Pamela R., et al.
Publicado: (2021)

The Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: Revisited
por: Kurian, Gino A., et al.
Publicado: (2016)

Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells
por: Kirby, Leslie A., et al.
Publicado: (2012)

Corrigendum: Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons
Publicado: (2021)

SB‐216763, a GSK‐3β inhibitor, protects against aldosterone‐induced cardiac, and renal injury by activating autophagy
por: Zhang, Yi‐De, et al.
Publicado: (2018)

Long-Lasting Antidepressant Action of Ketamine, but Not Glycogen Synthase Kinase-3 Inhibitor SB216763, in the Chronic Mild Stress Model of Mice
por: Ma, Xian-Cang, et al.
Publicado: (2013)

High-Fat Diet Increased Oxidative Stress and Mitochondrial Dysfunction Induced by Renal Ischemia-Reperfusion Injury in Rat
por: Prem, Priyanka N., et al.
Publicado: (2021)

Enhancement of Glycosaminoglycan-Rich Matrix Production in Human Marrow-Derived Mesenchymal Stem Cell Chondrogenic Culture by Lithium Chloride and SB216763 Treatment
por: Baghaban Eslaminejad, Mohamadreza, et al.
Publicado: (2011)

Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity
por: Shanmugam, Karthi, et al.
Publicado: (2018)

Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts
por: Kurian, Gino A, et al.
Publicado: (2010)

Lenticular mitoprotection. Part A: Monitoring mitochondrial depolarization with JC-1 and artifactual fluorescence by the glycogen synthase kinase-3β inhibitor, SB216763
por: Brooks, Morgan M., et al.
Publicado: (2013)

Standardization of in vitro Cell-based Model for Renal Ischemia and Reperfusion Injury
por: Kurian, Gino A., et al.
Publicado: (2014)

Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis
por: Gong, Weimin, et al.
Publicado: (2023)

Cardiac damage following renal ischemia reperfusion injury increased with excessive consumption of high fat diet but enhanced the cardiac resistance to reperfusion stress in rat()
por: Prem, Priyanka N., et al.
Publicado: (2023)

Effects of PM(2.5) on Cardio-Pulmonary Function Injury in Open Manganese Mine Workers
por: Huang, Yuanni, et al.
Publicado: (2019)

Role of cytokines in myocardial ischemia and reperfusion
por: Sharma, H. S., et al.
Publicado: (1997)

Platelets in Myocardial Ischemia/Reperfusion Injury
por: Schanze, Nancy, et al.
Publicado: (2022)

25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity
por: Lv, Suying, et al.
Publicado: (2020)

Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction
por: Chen, Yi-He, et al.
Publicado: (2020)

PM(2.5) exposure on daily cardio-respiratory mortality in Lima, Peru, from 2010 to 2016
por: Tapia, Vilma, et al.
Publicado: (2020)

TGF-β/Smad3 pathway enhances the cardio-protection of S1R/SIPR1 in in vitro ischemia-reperfusion myocardial cell model
por: Yang, Tingfang, et al.
Publicado: (2018)

Curcumin attenuates myocardial ischemia–reperfusion injury
por: Liu, Kun, et al.
Publicado: (2017)

Platelet Contributions to Myocardial Ischemia/Reperfusion Injury
por: Schanze, Nancy, et al.
Publicado: (2019)

Platelets, diabetes and myocardial ischemia/reperfusion injury
por: Russo, Isabella, et al.
Publicado: (2017)

Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation
por: Wu, Yuejin, et al.
Publicado: (2019)

Long-term administration of fisetin was not as effective as short term in ameliorating IR injury in isolated rat heart
por: Prem, Priyanka N., et al.
Publicado: (2022)

Age-associated global DNA hypermethylation augments the sensitivity of hearts towards ischemia-reperfusion injury
por: Boovarahan, Sri Rahavi, et al.
Publicado: (2022)

Muscone ameliorates myocardial ischemia‒reperfusion injury by promoting myocardial glycolysis
por: Gu, Xin, et al.
Publicado: (2023)

Hyperbaric oxygen protects against myocardial ischemia-reperfusion injury through inhibiting mitochondria dysfunction and autophagy
por: Chen, Wan, et al.
Publicado: (2020)

Sappanone A Prevents Left Ventricular Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model
por: Jo, Woori, et al.
Publicado: (2020)

Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model
por: Jo, Woori, et al.
Publicado: (2020)

Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
por: Qian, Weidong, et al.
Publicado: (2014)

Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury
por: Singhal, Arun K., et al.
Publicado: (2010)

Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit
por: Liu, MingJie, et al.
Publicado: (2014)

Protective approaches against myocardial ischemia reperfusion injury
por: Li, Xianchi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_re4ljljj25ok18d79rfikc2elm