The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2

Five new polyketides, including two chromones (1–2), two phenyl derivatives (4–5), and a tandyukusin derivative (6), along with five known polyketides (3 and 7–10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds were elucidated via det...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Yihao, Tan, Qi, Wu, Jianying, Chen, Tao, Yang, Wencong, She, Zhigang, Wang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672575/
https://www.ncbi.nlm.nih.gov/pubmed/37999390
http://dx.doi.org/10.3390/md21110566
_version_ 1785140423400882176
author Yin, Yihao
Tan, Qi
Wu, Jianying
Chen, Tao
Yang, Wencong
She, Zhigang
Wang, Bo
author_facet Yin, Yihao
Tan, Qi
Wu, Jianying
Chen, Tao
Yang, Wencong
She, Zhigang
Wang, Bo
author_sort Yin, Yihao
collection PubMed
description Five new polyketides, including two chromones (1–2), two phenyl derivatives (4–5), and a tandyukusin derivative (6), along with five known polyketides (3 and 7–10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds were elucidated via detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, and alkali hydrolysis were applied in the determination of the absolute configuration of the new compounds. In bioassays, 6 and 9 exhibited promising antifungal activities against Penicillium italicum, with an MIC value of 6.25 μM for both compounds. Moreover, 3 displayed moderate AChE inhibitory activity with an IC(50) value of 20.6 ± 0.3 μM.
format Online
Article
Text
id pubmed-10672575
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106725752023-10-28 The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2 Yin, Yihao Tan, Qi Wu, Jianying Chen, Tao Yang, Wencong She, Zhigang Wang, Bo Mar Drugs Article Five new polyketides, including two chromones (1–2), two phenyl derivatives (4–5), and a tandyukusin derivative (6), along with five known polyketides (3 and 7–10) were isolated from mangrove endophytic fungus Trichoderma lentiforme ML-P8-2. The planar structures of compounds were elucidated via detailed 1D, 2D NMR, and HR-ESI-MS analysis. ECD spectra, optical rotation values calculation, and alkali hydrolysis were applied in the determination of the absolute configuration of the new compounds. In bioassays, 6 and 9 exhibited promising antifungal activities against Penicillium italicum, with an MIC value of 6.25 μM for both compounds. Moreover, 3 displayed moderate AChE inhibitory activity with an IC(50) value of 20.6 ± 0.3 μM. MDPI 2023-10-28 /pmc/articles/PMC10672575/ /pubmed/37999390 http://dx.doi.org/10.3390/md21110566 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yin, Yihao
Tan, Qi
Wu, Jianying
Chen, Tao
Yang, Wencong
She, Zhigang
Wang, Bo
The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title_full The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title_fullStr The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title_full_unstemmed The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title_short The Polyketides with Antimicrobial Activities from a Mangrove Endophytic Fungus Trichoderma lentiforme ML-P8-2
title_sort polyketides with antimicrobial activities from a mangrove endophytic fungus trichoderma lentiforme ml-p8-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672575/
https://www.ncbi.nlm.nih.gov/pubmed/37999390
http://dx.doi.org/10.3390/md21110566
work_keys_str_mv AT yinyihao thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT tanqi thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT wujianying thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT chentao thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT yangwencong thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT shezhigang thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT wangbo thepolyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT yinyihao polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT tanqi polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT wujianying polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT chentao polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT yangwencong polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT shezhigang polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82
AT wangbo polyketideswithantimicrobialactivitiesfromamangroveendophyticfungustrichodermalentiformemlp82

Ejemplares similares