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Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome
Aquaporins (AQPs) are small transmembrane proteins able to facilitate the passive transport of water and small molecules throughout cells. Several studies have demonstrated that modulation of AQPs’ expression contributes to cancer development and progression. However, to date, very little is known a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672695/ https://www.ncbi.nlm.nih.gov/pubmed/38002749 http://dx.doi.org/10.3390/jcm12227137 |
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author | Camillo, Lara Esposto, Elia Gironi, Laura Cristina Airoldi, Chiara Alhamed, Shahd Abdullah Boldorini, Renzo Luciano Zavattaro, Elisa Savoia, Paola |
author_facet | Camillo, Lara Esposto, Elia Gironi, Laura Cristina Airoldi, Chiara Alhamed, Shahd Abdullah Boldorini, Renzo Luciano Zavattaro, Elisa Savoia, Paola |
author_sort | Camillo, Lara |
collection | PubMed |
description | Aquaporins (AQPs) are small transmembrane proteins able to facilitate the passive transport of water and small molecules throughout cells. Several studies have demonstrated that modulation of AQPs’ expression contributes to cancer development and progression. However, to date, very little is known about their involvement in malignant melanoma (MM) progression. In this retrospective observational study, we evaluated the correlation between AQP1, -8, and -9 expression and the clinical outcomes of 58 patients diagnosed with MM from 2014 to 2016, of which 14 were diagnosed as nodular melanoma (NM) and 44 as superficial spreading melanoma (SSM). In general, we found that AQPs were more highly expressed in SSM than NM, suggesting a potential correlation with prognosis. While analyzing the expression of each AQP, we discovered that AQP1 was associated with a specific body site and low mitotic index, AQP8 with a negative sentinel lymph node, and AQP9 with the Breslow thickness and lack of ulcerations. Together with the survival analysis performed in this study, our results suggest that the expression of AQP1, -8, and -9 could be correlated with a better prognosis for malignant melanoma. |
format | Online Article Text |
id | pubmed-10672695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106726952023-11-16 Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome Camillo, Lara Esposto, Elia Gironi, Laura Cristina Airoldi, Chiara Alhamed, Shahd Abdullah Boldorini, Renzo Luciano Zavattaro, Elisa Savoia, Paola J Clin Med Article Aquaporins (AQPs) are small transmembrane proteins able to facilitate the passive transport of water and small molecules throughout cells. Several studies have demonstrated that modulation of AQPs’ expression contributes to cancer development and progression. However, to date, very little is known about their involvement in malignant melanoma (MM) progression. In this retrospective observational study, we evaluated the correlation between AQP1, -8, and -9 expression and the clinical outcomes of 58 patients diagnosed with MM from 2014 to 2016, of which 14 were diagnosed as nodular melanoma (NM) and 44 as superficial spreading melanoma (SSM). In general, we found that AQPs were more highly expressed in SSM than NM, suggesting a potential correlation with prognosis. While analyzing the expression of each AQP, we discovered that AQP1 was associated with a specific body site and low mitotic index, AQP8 with a negative sentinel lymph node, and AQP9 with the Breslow thickness and lack of ulcerations. Together with the survival analysis performed in this study, our results suggest that the expression of AQP1, -8, and -9 could be correlated with a better prognosis for malignant melanoma. MDPI 2023-11-16 /pmc/articles/PMC10672695/ /pubmed/38002749 http://dx.doi.org/10.3390/jcm12227137 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Camillo, Lara Esposto, Elia Gironi, Laura Cristina Airoldi, Chiara Alhamed, Shahd Abdullah Boldorini, Renzo Luciano Zavattaro, Elisa Savoia, Paola Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title | Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title_full | Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title_fullStr | Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title_full_unstemmed | Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title_short | Aquaporin 1, Aquaporin 8, and Aquaporin 9 Expressions in Malignant Melanoma: A Possible Correlation with Prognosis and Clinical Outcome |
title_sort | aquaporin 1, aquaporin 8, and aquaporin 9 expressions in malignant melanoma: a possible correlation with prognosis and clinical outcome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672695/ https://www.ncbi.nlm.nih.gov/pubmed/38002749 http://dx.doi.org/10.3390/jcm12227137 |
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