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Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate

The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy...

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Autores principales: Radu (Dusman), Ramona-Daniela, Voicu, Manuela Elena, Prodana, Mariana, Demetrescu, Ioana, Anuta, Valentina, Draganescu, Doina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672849/
https://www.ncbi.nlm.nih.gov/pubmed/38005168
http://dx.doi.org/10.3390/ma16227237
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author Radu (Dusman), Ramona-Daniela
Voicu, Manuela Elena
Prodana, Mariana
Demetrescu, Ioana
Anuta, Valentina
Draganescu, Doina
author_facet Radu (Dusman), Ramona-Daniela
Voicu, Manuela Elena
Prodana, Mariana
Demetrescu, Ioana
Anuta, Valentina
Draganescu, Doina
author_sort Radu (Dusman), Ramona-Daniela
collection PubMed
description The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, for the composition (SEM-EDS), evidenced the presence of the polymer wires, with and without drug vancomycin loading. The wettability of the coatings was evaluated from the hydrophobic–hydrophilic point of view, and the characterization was completed with mechanical and electrochemical tests. All the electrochemical tests performed in simulated body fluid highlighted that PCL represents a barrier against corrosion processes. The quantitative method to evaluate the loading efficiency shows that almost 80% of the total loaded vancomycin is released within 144 h; after the initial burst at 24 h, a steady release of vancomycin is observed over 7 days. A kinetic model of the drug release was also constructed.
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spelling pubmed-106728492023-11-20 Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate Radu (Dusman), Ramona-Daniela Voicu, Manuela Elena Prodana, Mariana Demetrescu, Ioana Anuta, Valentina Draganescu, Doina Materials (Basel) Article The current study presents research about electrodeposition in relation to electrospinning PCL wires on a Zr substrate and loading the coating with vancomycin. The structural composition of the coatings was investigated via FT-IR analysis. The morphology evaluated using scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy, for the composition (SEM-EDS), evidenced the presence of the polymer wires, with and without drug vancomycin loading. The wettability of the coatings was evaluated from the hydrophobic–hydrophilic point of view, and the characterization was completed with mechanical and electrochemical tests. All the electrochemical tests performed in simulated body fluid highlighted that PCL represents a barrier against corrosion processes. The quantitative method to evaluate the loading efficiency shows that almost 80% of the total loaded vancomycin is released within 144 h; after the initial burst at 24 h, a steady release of vancomycin is observed over 7 days. A kinetic model of the drug release was also constructed. MDPI 2023-11-20 /pmc/articles/PMC10672849/ /pubmed/38005168 http://dx.doi.org/10.3390/ma16227237 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Radu (Dusman), Ramona-Daniela
Voicu, Manuela Elena
Prodana, Mariana
Demetrescu, Ioana
Anuta, Valentina
Draganescu, Doina
Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title_full Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title_fullStr Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title_full_unstemmed Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title_short Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate
title_sort electrospun pcl wires loaded with vancomycin on zirconium substrate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672849/
https://www.ncbi.nlm.nih.gov/pubmed/38005168
http://dx.doi.org/10.3390/ma16227237
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