Cargando…

Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report

Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percu...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yang-Won, Choi, Ho-Cheol, Yang, Won-Jeong, Koo, Byeong-Ju, Ahn, Jae-Kyeong, Lee, Jeong-Pyo, Na, Jae-Bum, Jo, Sa-Hong, Park, Sung-Eun, Won, Jung-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672895/
https://www.ncbi.nlm.nih.gov/pubmed/38003939
http://dx.doi.org/10.3390/medicina59111889
_version_ 1785140498236702720
author Kim, Yang-Won
Choi, Ho-Cheol
Yang, Won-Jeong
Koo, Byeong-Ju
Ahn, Jae-Kyeong
Lee, Jeong-Pyo
Na, Jae-Bum
Jo, Sa-Hong
Park, Sung-Eun
Won, Jung-Ho
author_facet Kim, Yang-Won
Choi, Ho-Cheol
Yang, Won-Jeong
Koo, Byeong-Ju
Ahn, Jae-Kyeong
Lee, Jeong-Pyo
Na, Jae-Bum
Jo, Sa-Hong
Park, Sung-Eun
Won, Jung-Ho
author_sort Kim, Yang-Won
collection PubMed
description Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percutaneous aspiration embolectomy using a guiding catheter and thrombolysis with recombinant tissue plasminogen activator (rtPA) are effective in treating SMA embolism. However, no reports on treating SMA embolism using rtPA administered via a microcatheter exist. Case presentation: A 64-year-old man with underlying atrial fibrillation presented with acute SMA embolism revealed using computed tomography (CT). rtPA (total 3 mg) was carefully administered into the occluded SMA through a microcatheter. No complications occurred, and complete revascularization of the SMA was revealed on follow-up CT. Conclusions: Compared with previous reports, this case report reveals that successful revascularization can be achieved using rtPA administered via a microcatheter, with a low dose of rtPA and a short duration of thrombolysis.
format Online
Article
Text
id pubmed-10672895
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106728952023-10-24 Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report Kim, Yang-Won Choi, Ho-Cheol Yang, Won-Jeong Koo, Byeong-Ju Ahn, Jae-Kyeong Lee, Jeong-Pyo Na, Jae-Bum Jo, Sa-Hong Park, Sung-Eun Won, Jung-Ho Medicina (Kaunas) Case Report Background: Acute mesenteric ischemia (AMI) is a life-threatening condition, and in 50% of patients, AMI is caused by acute superior mesenteric artery (SMA) embolism. Endovascular treatment is increasingly being considered the primary modality in selected cases. Many studies have reported that percutaneous aspiration embolectomy using a guiding catheter and thrombolysis with recombinant tissue plasminogen activator (rtPA) are effective in treating SMA embolism. However, no reports on treating SMA embolism using rtPA administered via a microcatheter exist. Case presentation: A 64-year-old man with underlying atrial fibrillation presented with acute SMA embolism revealed using computed tomography (CT). rtPA (total 3 mg) was carefully administered into the occluded SMA through a microcatheter. No complications occurred, and complete revascularization of the SMA was revealed on follow-up CT. Conclusions: Compared with previous reports, this case report reveals that successful revascularization can be achieved using rtPA administered via a microcatheter, with a low dose of rtPA and a short duration of thrombolysis. MDPI 2023-10-24 /pmc/articles/PMC10672895/ /pubmed/38003939 http://dx.doi.org/10.3390/medicina59111889 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kim, Yang-Won
Choi, Ho-Cheol
Yang, Won-Jeong
Koo, Byeong-Ju
Ahn, Jae-Kyeong
Lee, Jeong-Pyo
Na, Jae-Bum
Jo, Sa-Hong
Park, Sung-Eun
Won, Jung-Ho
Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title_full Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title_fullStr Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title_full_unstemmed Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title_short Microcatheter-Directed Thrombolysis Using Recombinant Tissue Plasminogen Activator for the Treatment of Acute Superior Mesenteric Artery Embolism: A Case Report
title_sort microcatheter-directed thrombolysis using recombinant tissue plasminogen activator for the treatment of acute superior mesenteric artery embolism: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672895/
https://www.ncbi.nlm.nih.gov/pubmed/38003939
http://dx.doi.org/10.3390/medicina59111889
work_keys_str_mv AT kimyangwon microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT choihocheol microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT yangwonjeong microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT koobyeongju microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT ahnjaekyeong microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT leejeongpyo microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT najaebum microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT josahong microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT parksungeun microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport
AT wonjungho microcatheterdirectedthrombolysisusingrecombinanttissueplasminogenactivatorforthetreatmentofacutesuperiormesentericarteryembolismacasereport