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Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital

Moulds are ubiquitous components of outdoor and indoor air and local conditions, temperature, humidity and season can influence their concentration in the air. The impact of these factors on mould exposure in hospitals and the resulting risk of infection for low to moderately immunocompromised patie...

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Autores principales: Puhlmann, Danuta, Bergmann, Dominic, Besier, Silke, Hogardt, Michael, Wichelhaus, Thomas A., Langhans, Sabine, Hack, Daniel, Reinheimer, Claudia, Vehreschild, Maria J. G. T., Jung, Jens, Kempf, Volkhard A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672964/
https://www.ncbi.nlm.nih.gov/pubmed/38004663
http://dx.doi.org/10.3390/microorganisms11112652
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author Puhlmann, Danuta
Bergmann, Dominic
Besier, Silke
Hogardt, Michael
Wichelhaus, Thomas A.
Langhans, Sabine
Hack, Daniel
Reinheimer, Claudia
Vehreschild, Maria J. G. T.
Jung, Jens
Kempf, Volkhard A. J.
author_facet Puhlmann, Danuta
Bergmann, Dominic
Besier, Silke
Hogardt, Michael
Wichelhaus, Thomas A.
Langhans, Sabine
Hack, Daniel
Reinheimer, Claudia
Vehreschild, Maria J. G. T.
Jung, Jens
Kempf, Volkhard A. J.
author_sort Puhlmann, Danuta
collection PubMed
description Moulds are ubiquitous components of outdoor and indoor air and local conditions, temperature, humidity and season can influence their concentration in the air. The impact of these factors on mould exposure in hospitals and the resulting risk of infection for low to moderately immunocompromised patients is unclear. In the present retrospective analysis for the years 2018 to 2022, the monthly determined mould contamination of the outdoor and indoor air at the University Hospital Frankfurt am Main is compared with the average air temperature and the relative humidity. Mould infections (Aspergillus spp., Mucorales) of low to moderately immunosuppressed patients of a haematological-oncological normal ward were determined clinically according to the criteria of the European Organisation for Research and Treatment of Cancer (EORTC, Brussels, Belgium) and of the National Reference Centre for Surveillance of Nosocomial Infections (NRC-NI, Berlin, Germany). The data revealed that in the summer months (May–October), increased mould contamination was detectable in the outdoor and indoor air compared to the winter months (November–April). The mould levels in the patient rooms followed the detection rates of the outdoor air. Two nosocomial Aspergillus infections, one nosocomial Mucorales (Rhizopus spp.) infection (according to both NRC-NI and EORTC criteria) and five Aspergillus spp. infections (according to EORTC criteria) occurred in 4299 treated patients (resulting in 41,500 patient days). In our study, the incidence density rate of contracting a nosocomial mould infection (n = 3) was approximately 0.07 per 1000 patient days and appears to be negligible.
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spelling pubmed-106729642023-10-28 Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital Puhlmann, Danuta Bergmann, Dominic Besier, Silke Hogardt, Michael Wichelhaus, Thomas A. Langhans, Sabine Hack, Daniel Reinheimer, Claudia Vehreschild, Maria J. G. T. Jung, Jens Kempf, Volkhard A. J. Microorganisms Article Moulds are ubiquitous components of outdoor and indoor air and local conditions, temperature, humidity and season can influence their concentration in the air. The impact of these factors on mould exposure in hospitals and the resulting risk of infection for low to moderately immunocompromised patients is unclear. In the present retrospective analysis for the years 2018 to 2022, the monthly determined mould contamination of the outdoor and indoor air at the University Hospital Frankfurt am Main is compared with the average air temperature and the relative humidity. Mould infections (Aspergillus spp., Mucorales) of low to moderately immunosuppressed patients of a haematological-oncological normal ward were determined clinically according to the criteria of the European Organisation for Research and Treatment of Cancer (EORTC, Brussels, Belgium) and of the National Reference Centre for Surveillance of Nosocomial Infections (NRC-NI, Berlin, Germany). The data revealed that in the summer months (May–October), increased mould contamination was detectable in the outdoor and indoor air compared to the winter months (November–April). The mould levels in the patient rooms followed the detection rates of the outdoor air. Two nosocomial Aspergillus infections, one nosocomial Mucorales (Rhizopus spp.) infection (according to both NRC-NI and EORTC criteria) and five Aspergillus spp. infections (according to EORTC criteria) occurred in 4299 treated patients (resulting in 41,500 patient days). In our study, the incidence density rate of contracting a nosocomial mould infection (n = 3) was approximately 0.07 per 1000 patient days and appears to be negligible. MDPI 2023-10-28 /pmc/articles/PMC10672964/ /pubmed/38004663 http://dx.doi.org/10.3390/microorganisms11112652 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Puhlmann, Danuta
Bergmann, Dominic
Besier, Silke
Hogardt, Michael
Wichelhaus, Thomas A.
Langhans, Sabine
Hack, Daniel
Reinheimer, Claudia
Vehreschild, Maria J. G. T.
Jung, Jens
Kempf, Volkhard A. J.
Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title_full Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title_fullStr Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title_full_unstemmed Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title_short Analysis of Mould Exposure of Immunosuppressed Patients at a German University Hospital
title_sort analysis of mould exposure of immunosuppressed patients at a german university hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672964/
https://www.ncbi.nlm.nih.gov/pubmed/38004663
http://dx.doi.org/10.3390/microorganisms11112652
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