Cargando…

Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care

Background and Objective: The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. Materials and Metho...

Descripción completa

Detalles Bibliográficos
Autores principales: Collée, Julie, Noel, Laure, Seidel, Laurence, Chantraine, Frédéric, Nisolle, Michelle, Henry, Laurie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672995/
https://www.ncbi.nlm.nih.gov/pubmed/38004079
http://dx.doi.org/10.3390/medicina59112030
_version_ 1785149570134573056
author Collée, Julie
Noel, Laure
Seidel, Laurence
Chantraine, Frédéric
Nisolle, Michelle
Henry, Laurie
author_facet Collée, Julie
Noel, Laure
Seidel, Laurence
Chantraine, Frédéric
Nisolle, Michelle
Henry, Laurie
author_sort Collée, Julie
collection PubMed
description Background and Objective: The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. Materials and Methods: This is a retrospective cohort study comparing two groups, 6557 patients who achieved pregnancy spontaneously and 330 patients who achieved pregnancy after ART, between January 2020 and December 2022. These patients were followed in the academic obstetrics department of Citadelle Hospital, Liège. The database of the ART center was compared with the database of the delivery unit to determine the cohort of patients who conceived after ART. Adverse maternal outcomes and MIC hospitalization rates were compared with between spontaneous pregnancies and ART groups. ART groups were also compared with each other. Results: The rate of hospitalization in maternal intensive care for patients who achieved pregnancy spontaneously was 12.1%, compared to 17.3% after ART. Comparing the rate of pre-eclampsia, 3.5% of spontaneous pregnancies were complicated by pre-eclampsia, while after ART, 10.9% of patients developed this complication during pregnancy. This rate was higher after IVF (12%) compared to intrauterine insemination and particularly after frozen embryo transfer (FET) in artificial cycle (17.9%). The birthweight of newborns after ART was also analyzed. A significant difference was obtained when comparing fresh embryo transfer with FET. Conclusions: Our study confirmed that FET in artificial cycle is a risk factor for pre-eclampsia and that fresh embryo transfer is associated with a higher rate of newborns with a lower percentile of birthweight. Our data showed that the rate of MIC hospitalization was significantly higher after ART but did not differ between groups.
format Online
Article
Text
id pubmed-10672995
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106729952023-11-17 Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care Collée, Julie Noel, Laure Seidel, Laurence Chantraine, Frédéric Nisolle, Michelle Henry, Laurie Medicina (Kaunas) Article Background and Objective: The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. Materials and Methods: This is a retrospective cohort study comparing two groups, 6557 patients who achieved pregnancy spontaneously and 330 patients who achieved pregnancy after ART, between January 2020 and December 2022. These patients were followed in the academic obstetrics department of Citadelle Hospital, Liège. The database of the ART center was compared with the database of the delivery unit to determine the cohort of patients who conceived after ART. Adverse maternal outcomes and MIC hospitalization rates were compared with between spontaneous pregnancies and ART groups. ART groups were also compared with each other. Results: The rate of hospitalization in maternal intensive care for patients who achieved pregnancy spontaneously was 12.1%, compared to 17.3% after ART. Comparing the rate of pre-eclampsia, 3.5% of spontaneous pregnancies were complicated by pre-eclampsia, while after ART, 10.9% of patients developed this complication during pregnancy. This rate was higher after IVF (12%) compared to intrauterine insemination and particularly after frozen embryo transfer (FET) in artificial cycle (17.9%). The birthweight of newborns after ART was also analyzed. A significant difference was obtained when comparing fresh embryo transfer with FET. Conclusions: Our study confirmed that FET in artificial cycle is a risk factor for pre-eclampsia and that fresh embryo transfer is associated with a higher rate of newborns with a lower percentile of birthweight. Our data showed that the rate of MIC hospitalization was significantly higher after ART but did not differ between groups. MDPI 2023-11-17 /pmc/articles/PMC10672995/ /pubmed/38004079 http://dx.doi.org/10.3390/medicina59112030 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Collée, Julie
Noel, Laure
Seidel, Laurence
Chantraine, Frédéric
Nisolle, Michelle
Henry, Laurie
Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title_full Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title_fullStr Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title_full_unstemmed Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title_short Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
title_sort impact of assisted reproduction techniques on adverse maternal outcomes and on the rate of hospitalization in maternal intensive care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672995/
https://www.ncbi.nlm.nih.gov/pubmed/38004079
http://dx.doi.org/10.3390/medicina59112030
work_keys_str_mv AT colleejulie impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare
AT noellaure impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare
AT seidellaurence impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare
AT chantrainefrederic impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare
AT nisollemichelle impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare
AT henrylaurie impactofassistedreproductiontechniquesonadversematernaloutcomesandontherateofhospitalizationinmaternalintensivecare