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Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions

Background and Objectives: In patients with peripheral artery disease, there is insufficient understanding of characteristics that predict successful revascularization of the lower extremity (LE) chronic total occlusions (CTOs) and baseline differences in demographic, clinical, and angiographic char...

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Autores principales: Kokkinidis, Damianos G., Schizas, Dimitrios, Pargaonkar, Sumant, Karamanis, Dimitrios, Mylonas, Konstantinos S., Hasemaki, Natasha, Palaiodimos, Leonidas, Varrias, Dimitrios, Tzavellas, Georgios, Siasos, Gerasimos, Klonaris, Christos, Kharawala, Amrin, Chlorogiannis, David-Dimitris, Georgopoulos, Sotirios, Bakoyiannis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673017/
https://www.ncbi.nlm.nih.gov/pubmed/38004078
http://dx.doi.org/10.3390/medicina59112029
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author Kokkinidis, Damianos G.
Schizas, Dimitrios
Pargaonkar, Sumant
Karamanis, Dimitrios
Mylonas, Konstantinos S.
Hasemaki, Natasha
Palaiodimos, Leonidas
Varrias, Dimitrios
Tzavellas, Georgios
Siasos, Gerasimos
Klonaris, Christos
Kharawala, Amrin
Chlorogiannis, David-Dimitris
Georgopoulos, Sotirios
Bakoyiannis, Christos
author_facet Kokkinidis, Damianos G.
Schizas, Dimitrios
Pargaonkar, Sumant
Karamanis, Dimitrios
Mylonas, Konstantinos S.
Hasemaki, Natasha
Palaiodimos, Leonidas
Varrias, Dimitrios
Tzavellas, Georgios
Siasos, Gerasimos
Klonaris, Christos
Kharawala, Amrin
Chlorogiannis, David-Dimitris
Georgopoulos, Sotirios
Bakoyiannis, Christos
author_sort Kokkinidis, Damianos G.
collection PubMed
description Background and Objectives: In patients with peripheral artery disease, there is insufficient understanding of characteristics that predict successful revascularization of the lower extremity (LE) chronic total occlusions (CTOs) and baseline differences in demographic, clinical, and angiographic characteristics in patients with LE CTO vs. non-CTO. We aim to explore these differences and predictors of successful revascularization among CTO patients. Materials and Methods: Two vascular centers enrolled LE-CTO patients who underwent endovascular revascularization. Data on demographics, clinical, angiographic, and interventional characteristics were collected. LE non-CTO arterial stenosis patients were compared. A total of 256 patients with LE revascularization procedures were studied; among them, 120 had CTOs and 136 had LE stenosis but no CTOs. Results: Aspirin use (Odds ratio, OR: 3.43; CI 1.32–8.88; p = 0.011) was a positive predictor whereas a history of malignancy (OR: 0.27; CI 0.09–0.80; p = 0.018) was a negative predictor of successful crossing in the CTO group. The CTO group had a higher history of myocardial infarction (29.2 vs. 18.3%, p = 0.05), end-stage renal disease (19.2 vs. 9.6%, p = 0.03), and chronic limb-threatening ischemia as the reason for revascularization (64.2 vs. 22.8%, p < 0.001). They were more likely to have advanced TransAtlantic Inter-Society Consensus (TASC) stages, multi-vessel revascularization procedures, longer lesions, and urgent treatment. Conclusions: The use of aspirin is a positive predictor whereas a history of malignancy is a negative predictor for successful crossing in CTO lesions. Additionally, LE-CTO patients have a higher incidence of comorbidities, which is expected given their higher disease burden. Successful endovascular re-vascularization can be associated with baseline clinical variables.
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spelling pubmed-106730172023-11-17 Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions Kokkinidis, Damianos G. Schizas, Dimitrios Pargaonkar, Sumant Karamanis, Dimitrios Mylonas, Konstantinos S. Hasemaki, Natasha Palaiodimos, Leonidas Varrias, Dimitrios Tzavellas, Georgios Siasos, Gerasimos Klonaris, Christos Kharawala, Amrin Chlorogiannis, David-Dimitris Georgopoulos, Sotirios Bakoyiannis, Christos Medicina (Kaunas) Article Background and Objectives: In patients with peripheral artery disease, there is insufficient understanding of characteristics that predict successful revascularization of the lower extremity (LE) chronic total occlusions (CTOs) and baseline differences in demographic, clinical, and angiographic characteristics in patients with LE CTO vs. non-CTO. We aim to explore these differences and predictors of successful revascularization among CTO patients. Materials and Methods: Two vascular centers enrolled LE-CTO patients who underwent endovascular revascularization. Data on demographics, clinical, angiographic, and interventional characteristics were collected. LE non-CTO arterial stenosis patients were compared. A total of 256 patients with LE revascularization procedures were studied; among them, 120 had CTOs and 136 had LE stenosis but no CTOs. Results: Aspirin use (Odds ratio, OR: 3.43; CI 1.32–8.88; p = 0.011) was a positive predictor whereas a history of malignancy (OR: 0.27; CI 0.09–0.80; p = 0.018) was a negative predictor of successful crossing in the CTO group. The CTO group had a higher history of myocardial infarction (29.2 vs. 18.3%, p = 0.05), end-stage renal disease (19.2 vs. 9.6%, p = 0.03), and chronic limb-threatening ischemia as the reason for revascularization (64.2 vs. 22.8%, p < 0.001). They were more likely to have advanced TransAtlantic Inter-Society Consensus (TASC) stages, multi-vessel revascularization procedures, longer lesions, and urgent treatment. Conclusions: The use of aspirin is a positive predictor whereas a history of malignancy is a negative predictor for successful crossing in CTO lesions. Additionally, LE-CTO patients have a higher incidence of comorbidities, which is expected given their higher disease burden. Successful endovascular re-vascularization can be associated with baseline clinical variables. MDPI 2023-11-17 /pmc/articles/PMC10673017/ /pubmed/38004078 http://dx.doi.org/10.3390/medicina59112029 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kokkinidis, Damianos G.
Schizas, Dimitrios
Pargaonkar, Sumant
Karamanis, Dimitrios
Mylonas, Konstantinos S.
Hasemaki, Natasha
Palaiodimos, Leonidas
Varrias, Dimitrios
Tzavellas, Georgios
Siasos, Gerasimos
Klonaris, Christos
Kharawala, Amrin
Chlorogiannis, David-Dimitris
Georgopoulos, Sotirios
Bakoyiannis, Christos
Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title_full Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title_fullStr Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title_full_unstemmed Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title_short Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
title_sort differences between lower extremity arterial occlusion vs. stenosis and predictors of successful endovascular interventions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673017/
https://www.ncbi.nlm.nih.gov/pubmed/38004078
http://dx.doi.org/10.3390/medicina59112029
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