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Electric Fields at the Lipid Membrane Interface

This review presents a comprehensive analysis of electric field distribution at the water–lipid membrane interface in the context of its relationship to various biochemical problems. The main attention is paid to the methodological aspects of bioelectrochemical techniques and quantitative analysis o...

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Detalles Bibliográficos
Autor principal: Ermakov, Yury A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673053/
https://www.ncbi.nlm.nih.gov/pubmed/37999369
http://dx.doi.org/10.3390/membranes13110883
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author Ermakov, Yury A.
author_facet Ermakov, Yury A.
author_sort Ermakov, Yury A.
collection PubMed
description This review presents a comprehensive analysis of electric field distribution at the water–lipid membrane interface in the context of its relationship to various biochemical problems. The main attention is paid to the methodological aspects of bioelectrochemical techniques and quantitative analysis of electrical phenomena caused by the ionization and hydration of the membrane–water interface associated with the phase state of lipids. One of the objectives is to show the unique possibility of controlling changes in the structure of the lipid bilayer initiated by various membrane-active agents that results in electrostatic phenomena at the surface of lipid models of biomembranes—liposomes, planar lipid bilayer membranes (BLMs) and monolayers. A set of complicated experimental facts revealed in different years is analyzed here in order of increasing complexity: from the adsorption of biologically significant inorganic ions and phase rearrangements in the presence of multivalent cations to the adsorption and incorporation of pharmacologically significant compounds into the lipid bilayer, and formation of the layers of macromolecules of different types.
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spelling pubmed-106730532023-11-16 Electric Fields at the Lipid Membrane Interface Ermakov, Yury A. Membranes (Basel) Review This review presents a comprehensive analysis of electric field distribution at the water–lipid membrane interface in the context of its relationship to various biochemical problems. The main attention is paid to the methodological aspects of bioelectrochemical techniques and quantitative analysis of electrical phenomena caused by the ionization and hydration of the membrane–water interface associated with the phase state of lipids. One of the objectives is to show the unique possibility of controlling changes in the structure of the lipid bilayer initiated by various membrane-active agents that results in electrostatic phenomena at the surface of lipid models of biomembranes—liposomes, planar lipid bilayer membranes (BLMs) and monolayers. A set of complicated experimental facts revealed in different years is analyzed here in order of increasing complexity: from the adsorption of biologically significant inorganic ions and phase rearrangements in the presence of multivalent cations to the adsorption and incorporation of pharmacologically significant compounds into the lipid bilayer, and formation of the layers of macromolecules of different types. MDPI 2023-11-16 /pmc/articles/PMC10673053/ /pubmed/37999369 http://dx.doi.org/10.3390/membranes13110883 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ermakov, Yury A.
Electric Fields at the Lipid Membrane Interface
title Electric Fields at the Lipid Membrane Interface
title_full Electric Fields at the Lipid Membrane Interface
title_fullStr Electric Fields at the Lipid Membrane Interface
title_full_unstemmed Electric Fields at the Lipid Membrane Interface
title_short Electric Fields at the Lipid Membrane Interface
title_sort electric fields at the lipid membrane interface
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673053/
https://www.ncbi.nlm.nih.gov/pubmed/37999369
http://dx.doi.org/10.3390/membranes13110883
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