Cargando…

Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy

Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases. Another HSV-based drug, beremagene geperpavec (B-VEC),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Palomäki, Jussi, Kalke, Kiira, Orpana, Julius, Lund, Liisa, Frejborg, Fanny, Paavilainen, Henrik, Järveläinen, Hannu, Hukkanen, Veijo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673056/ https://www.ncbi.nlm.nih.gov/pubmed/38004669 http://dx.doi.org/10.3390/microorganisms11112657

Ejemplares similares

The In Vitro Replication, Spread, and Oncolytic Potential of Finnish Circulating Strains of Herpes Simplex Virus Type 1
por: Kalke, Kiira, et al.
Publicado: (2022)

Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity
por: Kalke, Kiira, et al.
Publicado: (2020)

Swarms of chemically modified antiviral siRNA targeting herpes simplex virus infection in human corneal epithelial cells
por: Kalke, Kiira, et al.
Publicado: (2022)

Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity
por: Levanova, Alesia A., et al.
Publicado: (2020)

The material properties of naked mole-rat hyaluronan
por: Kulaberoglu, Yavuz, et al.
Publicado: (2019)

Abundance and size of hyaluronan in naked mole-rat tissues and plasma
por: del Marmol, Delphine, et al.
Publicado: (2021)

Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection
por: Bowen, Christopher D., et al.
Publicado: (2019)

High molecular weight hyaluronan mediates the cancer resistance of the naked mole-rat
por: Tian, Xiao, et al.
Publicado: (2013)

Native RNA Purification Method for Small RNA Molecules Based on Asymmetrical Flow Field-Flow Fractionation
por: Levanova, Alesia A., et al.
Publicado: (2022)

Naked Mole Rat
por: Buffenstein, Rochelle, et al.
Publicado: (2012)

Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
por: Takasugi, Masaki, et al.
Publicado: (2020)

A Herpes Simplex Virus-Derived Replicative Vector Expressing LIF Limits Experimental Demyelinating Disease and Modulates Autoimmunity
por: Nygårdas, Michaela, et al.
Publicado: (2013)

Enzymatically Produced Pools of Canonical and Dicer-Substrate siRNA Molecules Display Comparable Gene Silencing and Antiviral Activities against Herpes Simplex Virus
por: Romanovskaya, Alesia, et al.
Publicado: (2012)

Genome Stability Maintenance in Naked Mole-Rat
por: Petruseva, I. O., et al.
Publicado: (2017)

Extreme Longevity Mechanisms in the Naked Mole Rat
por: Buffenstein, Shelley
Publicado: (2020)

The metabolomic signature of extreme longevity: naked mole rats versus mice
por: Viltard, Mélanie, et al.
Publicado: (2019)

Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1
por: Damour, Alexia, et al.
Publicado: (2021)

Human cancer, the naked mole rat and faunal turnovers
por: Bredberg, Anders, et al.
Publicado: (2019)

Multiple thymi and no thymic involution in naked mole rats?
por: Pawelec, Graham
Publicado: (2021)

EPIGENETIC AGING OF THE DEMOGRAPHICALLY NONAGING NAKED MOLE RAT
por: Kerepesi, Csaba
Publicado: (2022)

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses
por: Ylösmäki, Erkko, et al.
Publicado: (2018)

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology
por: Buffenstein, Rochelle, et al.
Publicado: (2021)

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat
por: Zheng, Zhizhong, et al.
Publicado: (2022)

Fossorial adaptations in African mole-rats (Bathyergidae) and the unique appendicular phenotype of naked mole-rats
por: Montoya-Sanhueza, Germán, et al.
Publicado: (2022)

Plasma oxidative stress in reproduction of two eusocial African mole-rat species, the naked mole-rat and the Damaraland mole-rat
por: Jacobs, Paul Juan, et al.
Publicado: (2021)

Functional Characteristics of the Naked Mole Rat μ-Opioid Receptor
por: Busch-Dienstfertig, Melanie, et al.
Publicado: (2013)

Unraveling the message: insights into comparative genomics of the naked mole-rat
por: Lewis, Kaitlyn N., et al.
Publicado: (2016)

Comparative study of macrophages in naked mole rats and ICR mice
por: Cheng, Jishuai, et al.
Publicado: (2017)

Unraveling the gut microbiome of the long-lived naked mole-rat
por: Debebe, Tewodros, et al.
Publicado: (2017)

Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue
por: Faulkes, Chris G., et al.
Publicado: (2019)

Naked mole‐rats are extremely resistant to post‐traumatic osteoarthritis
por: Taguchi, Taketo, et al.
Publicado: (2020)

Characterization of an active LINE-1 in the naked mole-rat genome
por: Yamaguchi, Shunichi, et al.
Publicado: (2021)

DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat
por: Boughey, Harvey, et al.
Publicado: (2021)

Epigenetic aging of the demographically non-aging naked mole-rat
por: Kerepesi, Csaba, et al.
Publicado: (2022)

Auditory brainstem development of naked mole-rats (Heterocephalus glaber)
por: McCullagh, Elizabeth A., et al.
Publicado: (2022)

Carcinogenesis resistance in the longest‐lived rodent, the naked mole‐rat
por: Yamamura, Yuki, et al.
Publicado: (2022)

The combined effects of irradiation and herpes simplex virus type 1 infection on an immortal gingival cell line
por: Turunen, Aaro, et al.
Publicado: (2014)

Genome sequencing reveals insights into physiology and longevity of the naked mole rat
por: Kim, Eun Bae, et al.
Publicado: (2011)

Blunted Neuronal Calcium Response to Hypoxia in Naked Mole-Rat Hippocampus
por: Peterson, Bethany L., et al.
Publicado: (2012)

The naked mole rat genome: understanding aging through genome analysis
por: Gladyshev, Vadim N., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lmd9s58f5l0o55jug77q7o3l5m