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Thyroid Disease and Systemic Lupus Erythematosus

Background and Objectives: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations spanning across all organ systems, the relationship of SLE with thyroid disorders needs investigation. In parti...

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Autores principales: Athanassiou, Lambros, Kostoglou-Athanassiou, Ifigenia, Kaiafa, Georgia, Tsakiridis, Pavlos, Koukosias, Nikolaos, Mitsoulis, Spyridon, Savopoulos, Christos, Athanassiou, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673127/
https://www.ncbi.nlm.nih.gov/pubmed/38003960
http://dx.doi.org/10.3390/medicina59111911
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author Athanassiou, Lambros
Kostoglou-Athanassiou, Ifigenia
Kaiafa, Georgia
Tsakiridis, Pavlos
Koukosias, Nikolaos
Mitsoulis, Spyridon
Savopoulos, Christos
Athanassiou, Panagiotis
author_facet Athanassiou, Lambros
Kostoglou-Athanassiou, Ifigenia
Kaiafa, Georgia
Tsakiridis, Pavlos
Koukosias, Nikolaos
Mitsoulis, Spyridon
Savopoulos, Christos
Athanassiou, Panagiotis
author_sort Athanassiou, Lambros
collection PubMed
description Background and Objectives: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations spanning across all organ systems, the relationship of SLE with thyroid disorders needs investigation. In particular, the relationship of SLE with autoimmune thyroid disease has attracted the interest of the research community. The aim was to evaluate the relationship of SLE with autoimmune thyroid disease. Materials and Methods: A cohort of 45 consecutive patients with a mean age of 47.97 years (range 21–79 years) and 45 age- and sex-matched controls were prospectively studied over a period of 12 months for the presence of thyroid disease and the prevalence of antithyroid antibodies. Results: Four patients (8.9%) were found to suffer from primary hypothyroidism, five (11.11%) from subclinical hypothyroidism and one (2.22%) from hyperthyroidism, whereas one (2.22%) of the controls had primary hypothyroidism and one (2.22%) had hyperthyroidism. Five patients (11.11%) had a thyroid hormone profile that was compatible with the presence of euthyroid sick syndrome. Thyroid peroxidase (TPOab) and thyroglobulin (Tgab) antibodies were detected in 20/45 and 15/45 of the SLE population and in 7/45 and 5/45 of the controls, respectively (p < 0.05, chi-square test). Conclusions: In conclusion, the incidence of clinical thyroid disease is greater amongst SLE patients than in a control population, and in a significant number of these patients, antithyroid antibodies are detectable. Thus, a subset of lupus patients appears to be predisposed to the development of thyroid disease, and this should be considered when evaluating patients with SLE.
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spelling pubmed-106731272023-10-29 Thyroid Disease and Systemic Lupus Erythematosus Athanassiou, Lambros Kostoglou-Athanassiou, Ifigenia Kaiafa, Georgia Tsakiridis, Pavlos Koukosias, Nikolaos Mitsoulis, Spyridon Savopoulos, Christos Athanassiou, Panagiotis Medicina (Kaunas) Article Background and Objectives: Thyroid disease has been associated with autoimmune disorders. As systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations spanning across all organ systems, the relationship of SLE with thyroid disorders needs investigation. In particular, the relationship of SLE with autoimmune thyroid disease has attracted the interest of the research community. The aim was to evaluate the relationship of SLE with autoimmune thyroid disease. Materials and Methods: A cohort of 45 consecutive patients with a mean age of 47.97 years (range 21–79 years) and 45 age- and sex-matched controls were prospectively studied over a period of 12 months for the presence of thyroid disease and the prevalence of antithyroid antibodies. Results: Four patients (8.9%) were found to suffer from primary hypothyroidism, five (11.11%) from subclinical hypothyroidism and one (2.22%) from hyperthyroidism, whereas one (2.22%) of the controls had primary hypothyroidism and one (2.22%) had hyperthyroidism. Five patients (11.11%) had a thyroid hormone profile that was compatible with the presence of euthyroid sick syndrome. Thyroid peroxidase (TPOab) and thyroglobulin (Tgab) antibodies were detected in 20/45 and 15/45 of the SLE population and in 7/45 and 5/45 of the controls, respectively (p < 0.05, chi-square test). Conclusions: In conclusion, the incidence of clinical thyroid disease is greater amongst SLE patients than in a control population, and in a significant number of these patients, antithyroid antibodies are detectable. Thus, a subset of lupus patients appears to be predisposed to the development of thyroid disease, and this should be considered when evaluating patients with SLE. MDPI 2023-10-29 /pmc/articles/PMC10673127/ /pubmed/38003960 http://dx.doi.org/10.3390/medicina59111911 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Athanassiou, Lambros
Kostoglou-Athanassiou, Ifigenia
Kaiafa, Georgia
Tsakiridis, Pavlos
Koukosias, Nikolaos
Mitsoulis, Spyridon
Savopoulos, Christos
Athanassiou, Panagiotis
Thyroid Disease and Systemic Lupus Erythematosus
title Thyroid Disease and Systemic Lupus Erythematosus
title_full Thyroid Disease and Systemic Lupus Erythematosus
title_fullStr Thyroid Disease and Systemic Lupus Erythematosus
title_full_unstemmed Thyroid Disease and Systemic Lupus Erythematosus
title_short Thyroid Disease and Systemic Lupus Erythematosus
title_sort thyroid disease and systemic lupus erythematosus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673127/
https://www.ncbi.nlm.nih.gov/pubmed/38003960
http://dx.doi.org/10.3390/medicina59111911
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