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Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents

Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models...

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Detalles Bibliográficos
Autores principales: Oda, Asahi, Hakamata, Yoji, Kobayashi, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673227/
https://www.ncbi.nlm.nih.gov/pubmed/37999210
http://dx.doi.org/10.3390/metabo13111114
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author Oda, Asahi
Hakamata, Yoji
Kobayashi, Eiji
author_facet Oda, Asahi
Hakamata, Yoji
Kobayashi, Eiji
author_sort Oda, Asahi
collection PubMed
description Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models. While a test substance can be administered either before or after an event, healthy foods are generally pre-administered prophylactically in experiments. Pre-administration may have the potential to elevate the blood concentration of the active substance sufficiently prior to the event and/or induce adaptive changes in the ischemic tolerance of the recipient through long-term pre-administration. Based on the recently reported 2-week pre-administration of blackberries in a rat model, we investigated the pre-administration of blackberry extracts in a hyperlipidemia model using Mongolian gerbils. We then discussed the effects of the pre-administration on the treated animals before an ischemic event.
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spelling pubmed-106732272023-10-28 Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents Oda, Asahi Hakamata, Yoji Kobayashi, Eiji Metabolites Commentary Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models. While a test substance can be administered either before or after an event, healthy foods are generally pre-administered prophylactically in experiments. Pre-administration may have the potential to elevate the blood concentration of the active substance sufficiently prior to the event and/or induce adaptive changes in the ischemic tolerance of the recipient through long-term pre-administration. Based on the recently reported 2-week pre-administration of blackberries in a rat model, we investigated the pre-administration of blackberry extracts in a hyperlipidemia model using Mongolian gerbils. We then discussed the effects of the pre-administration on the treated animals before an ischemic event. MDPI 2023-10-28 /pmc/articles/PMC10673227/ /pubmed/37999210 http://dx.doi.org/10.3390/metabo13111114 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Oda, Asahi
Hakamata, Yoji
Kobayashi, Eiji
Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title_full Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title_fullStr Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title_full_unstemmed Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title_short Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
title_sort pre-administration of blackberry extracts in induced ischemia reperfusion events in rodents
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673227/
https://www.ncbi.nlm.nih.gov/pubmed/37999210
http://dx.doi.org/10.3390/metabo13111114
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