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Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents
Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673227/ https://www.ncbi.nlm.nih.gov/pubmed/37999210 http://dx.doi.org/10.3390/metabo13111114 |
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author | Oda, Asahi Hakamata, Yoji Kobayashi, Eiji |
author_facet | Oda, Asahi Hakamata, Yoji Kobayashi, Eiji |
author_sort | Oda, Asahi |
collection | PubMed |
description | Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models. While a test substance can be administered either before or after an event, healthy foods are generally pre-administered prophylactically in experiments. Pre-administration may have the potential to elevate the blood concentration of the active substance sufficiently prior to the event and/or induce adaptive changes in the ischemic tolerance of the recipient through long-term pre-administration. Based on the recently reported 2-week pre-administration of blackberries in a rat model, we investigated the pre-administration of blackberry extracts in a hyperlipidemia model using Mongolian gerbils. We then discussed the effects of the pre-administration on the treated animals before an ischemic event. |
format | Online Article Text |
id | pubmed-10673227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106732272023-10-28 Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents Oda, Asahi Hakamata, Yoji Kobayashi, Eiji Metabolites Commentary Blackberries are abundant in substances that have antioxidative and other effects, and technologies for enhancing the effectiveness of their incorporation into the body are being developed. The effectiveness of such substances has been investigated in various models, including rodent ischemia models. While a test substance can be administered either before or after an event, healthy foods are generally pre-administered prophylactically in experiments. Pre-administration may have the potential to elevate the blood concentration of the active substance sufficiently prior to the event and/or induce adaptive changes in the ischemic tolerance of the recipient through long-term pre-administration. Based on the recently reported 2-week pre-administration of blackberries in a rat model, we investigated the pre-administration of blackberry extracts in a hyperlipidemia model using Mongolian gerbils. We then discussed the effects of the pre-administration on the treated animals before an ischemic event. MDPI 2023-10-28 /pmc/articles/PMC10673227/ /pubmed/37999210 http://dx.doi.org/10.3390/metabo13111114 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Oda, Asahi Hakamata, Yoji Kobayashi, Eiji Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title | Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title_full | Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title_fullStr | Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title_full_unstemmed | Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title_short | Pre-Administration of Blackberry Extracts in Induced Ischemia Reperfusion Events in Rodents |
title_sort | pre-administration of blackberry extracts in induced ischemia reperfusion events in rodents |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673227/ https://www.ncbi.nlm.nih.gov/pubmed/37999210 http://dx.doi.org/10.3390/metabo13111114 |
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