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Postmortem Alteration of Purine Metabolism in Coronary Artery Disease
A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this pathway in postmortem changes needs t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673240/ https://www.ncbi.nlm.nih.gov/pubmed/37999231 http://dx.doi.org/10.3390/metabo13111135 |
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author | Somtua, Phakchira Jaikang, Churdsak Konguthaithip, Giatgong Intui, Kanicnan Watcharakhom, Somlada O’Brien, Timothy E. Amornlertwatana, Yutti |
author_facet | Somtua, Phakchira Jaikang, Churdsak Konguthaithip, Giatgong Intui, Kanicnan Watcharakhom, Somlada O’Brien, Timothy E. Amornlertwatana, Yutti |
author_sort | Somtua, Phakchira |
collection | PubMed |
description | A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this pathway in postmortem changes needs to be explored. This study investigated the levels of blood purine metabolites in CAD after death. Heart blood samples (n = 60) were collected and divided into CAD (n = 23) and control groups (n = 37). Purine metabolites were measured via proton nuclear magnetic resonance. Guanosine triphosphate (GTP), nicotinamide adenine dinucleotide (NAD), and xanthine levels significantly decreased (p < 0.05); conversely, adenine and deoxyribose 5-phosphate levels significantly increased (p < 0.05) in the CAD group compared to the control group. Decreasing xanthine levels may serve as a marker for predicting the cause of death in CAD (AUC = 0.7). Our findings suggest that the purine pathway was interrupted by physiological processes after death, causing the metabolism of the deceased to differ from that of the living. Additionally, xanthine levels should be studied further to better understand their relationship with CAD and used as a biomarker for CAD diagnosis under decomposition and skeletonization settings. |
format | Online Article Text |
id | pubmed-10673240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106732402023-11-08 Postmortem Alteration of Purine Metabolism in Coronary Artery Disease Somtua, Phakchira Jaikang, Churdsak Konguthaithip, Giatgong Intui, Kanicnan Watcharakhom, Somlada O’Brien, Timothy E. Amornlertwatana, Yutti Metabolites Article A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this pathway in postmortem changes needs to be explored. This study investigated the levels of blood purine metabolites in CAD after death. Heart blood samples (n = 60) were collected and divided into CAD (n = 23) and control groups (n = 37). Purine metabolites were measured via proton nuclear magnetic resonance. Guanosine triphosphate (GTP), nicotinamide adenine dinucleotide (NAD), and xanthine levels significantly decreased (p < 0.05); conversely, adenine and deoxyribose 5-phosphate levels significantly increased (p < 0.05) in the CAD group compared to the control group. Decreasing xanthine levels may serve as a marker for predicting the cause of death in CAD (AUC = 0.7). Our findings suggest that the purine pathway was interrupted by physiological processes after death, causing the metabolism of the deceased to differ from that of the living. Additionally, xanthine levels should be studied further to better understand their relationship with CAD and used as a biomarker for CAD diagnosis under decomposition and skeletonization settings. MDPI 2023-11-08 /pmc/articles/PMC10673240/ /pubmed/37999231 http://dx.doi.org/10.3390/metabo13111135 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Somtua, Phakchira Jaikang, Churdsak Konguthaithip, Giatgong Intui, Kanicnan Watcharakhom, Somlada O’Brien, Timothy E. Amornlertwatana, Yutti Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title | Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title_full | Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title_fullStr | Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title_full_unstemmed | Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title_short | Postmortem Alteration of Purine Metabolism in Coronary Artery Disease |
title_sort | postmortem alteration of purine metabolism in coronary artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673240/ https://www.ncbi.nlm.nih.gov/pubmed/37999231 http://dx.doi.org/10.3390/metabo13111135 |
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