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Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients

The Controlling Nutritional Status (CONUT) score is a simple screening tool able to assess poor nutritional status as well as to predict clinical adverse outcomes in different clinical settings. No data are available in older patients with chronic obstructive pulmonary disease (COPD). This study aim...

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Autores principales: Lo Buglio, Aurelio, Scioscia, Giulia, Bellanti, Francesco, Tondo, Pasquale, Soccio, Piera, Natale, Matteo Pio, Lacedonia, Donato, Vendemiale, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673254/
https://www.ncbi.nlm.nih.gov/pubmed/37999219
http://dx.doi.org/10.3390/metabo13111123
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author Lo Buglio, Aurelio
Scioscia, Giulia
Bellanti, Francesco
Tondo, Pasquale
Soccio, Piera
Natale, Matteo Pio
Lacedonia, Donato
Vendemiale, Gianluigi
author_facet Lo Buglio, Aurelio
Scioscia, Giulia
Bellanti, Francesco
Tondo, Pasquale
Soccio, Piera
Natale, Matteo Pio
Lacedonia, Donato
Vendemiale, Gianluigi
author_sort Lo Buglio, Aurelio
collection PubMed
description The Controlling Nutritional Status (CONUT) score is a simple screening tool able to assess poor nutritional status as well as to predict clinical adverse outcomes in different clinical settings. No data are available in older patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the CONUT score as a predictor of frequent exacerbations. We retrospectively enrolled 222 patients aged 65 years or older, classified in two groups according to the number of exacerbations (or hospitalizations because AECOPD) during the previous year. The two groups were further divided according to low (<5) or high (≥5) CONUT scores. A total of 67.2% of frequent exacerbators had a high CONUT score. These patients exhibited a significantly higher CAT score, lower FEV1 percentage value, and higher prevalence of severe GOLD stages compared to those with low CONUT. Multivariate analysis showed that a CONUT score ≥ 5 was the best independent predictor (OR 20.740, p < 0.001) of the occurrence of ≥2 exacerbations (or 1 hospitalization) during the previous year. The CONUT score seemed to have a high prognostic value for frequent exacerbations for COPD in older patients. The predictive role of different CONUT score cut-off values needs to be validated in larger COPD populations in future multi-center, prospective clinical studies.
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spelling pubmed-106732542023-11-02 Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients Lo Buglio, Aurelio Scioscia, Giulia Bellanti, Francesco Tondo, Pasquale Soccio, Piera Natale, Matteo Pio Lacedonia, Donato Vendemiale, Gianluigi Metabolites Article The Controlling Nutritional Status (CONUT) score is a simple screening tool able to assess poor nutritional status as well as to predict clinical adverse outcomes in different clinical settings. No data are available in older patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the CONUT score as a predictor of frequent exacerbations. We retrospectively enrolled 222 patients aged 65 years or older, classified in two groups according to the number of exacerbations (or hospitalizations because AECOPD) during the previous year. The two groups were further divided according to low (<5) or high (≥5) CONUT scores. A total of 67.2% of frequent exacerbators had a high CONUT score. These patients exhibited a significantly higher CAT score, lower FEV1 percentage value, and higher prevalence of severe GOLD stages compared to those with low CONUT. Multivariate analysis showed that a CONUT score ≥ 5 was the best independent predictor (OR 20.740, p < 0.001) of the occurrence of ≥2 exacerbations (or 1 hospitalization) during the previous year. The CONUT score seemed to have a high prognostic value for frequent exacerbations for COPD in older patients. The predictive role of different CONUT score cut-off values needs to be validated in larger COPD populations in future multi-center, prospective clinical studies. MDPI 2023-11-02 /pmc/articles/PMC10673254/ /pubmed/37999219 http://dx.doi.org/10.3390/metabo13111123 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lo Buglio, Aurelio
Scioscia, Giulia
Bellanti, Francesco
Tondo, Pasquale
Soccio, Piera
Natale, Matteo Pio
Lacedonia, Donato
Vendemiale, Gianluigi
Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title_full Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title_fullStr Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title_full_unstemmed Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title_short Controlling Nutritional Status Score as a Predictor for Chronic Obstructive Pulmonary Disease Exacerbation Risk in Elderly Patients
title_sort controlling nutritional status score as a predictor for chronic obstructive pulmonary disease exacerbation risk in elderly patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673254/
https://www.ncbi.nlm.nih.gov/pubmed/37999219
http://dx.doi.org/10.3390/metabo13111123
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