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Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children

Background and Objectives: Irisin is an adipo-myokine with potential metabolic effects in the body, and its association with childhood obesity is still controversial. This study aimed to investigate the relationship between serum irisin levels and anthropometric parameters, body composition, metabol...

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Autores principales: Esin, Kübra, Batirel, Saime, Ülfer, Gözde, Yigit, Pakize, Sanlier, Nevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673282/
https://www.ncbi.nlm.nih.gov/pubmed/38004003
http://dx.doi.org/10.3390/medicina59111954
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author Esin, Kübra
Batirel, Saime
Ülfer, Gözde
Yigit, Pakize
Sanlier, Nevin
author_facet Esin, Kübra
Batirel, Saime
Ülfer, Gözde
Yigit, Pakize
Sanlier, Nevin
author_sort Esin, Kübra
collection PubMed
description Background and Objectives: Irisin is an adipo-myokine with potential metabolic effects in the body, and its association with childhood obesity is still controversial. This study aimed to investigate the relationship between serum irisin levels and anthropometric parameters, body composition, metabolic profiles, leptin, and adiponectin in obese and normal-weight children. Methods: The study sample consisted of a total of 80 children aged 6–10, including 44 obese children (BMI ≥ 97th percentile) and 36 normal-weight children. Anthropometric parameters were measured. Body composition was determined with the use of the Bioelectrical Impedance Analysis (BIA) method. Metabolic profiles, as well as irisin, leptin, and adiponectin levels, were analyzed. Results: Anthropometric parameters and body composition were found to be significantly different between the obese and normal-weight groups (p < 0.05). Fasting blood glucose, insulin, HOMA-IR, and leptin levels were found to be significantly higher in the obese group, while the normal-weight group had significantly higher HDL cholesterol and adiponectin levels (p < 0.05). Serum irisin levels did not differ between the obese and normal-weight groups, or based on sex, vitamin D levels, and insulin resistance status. There was also no statistically significant correlation between serum irisin levels and anthropometric parameters, metabolic profile, leptin, and adiponectin. Conclusions: The study concluded that the obese children who participated in this study had high leptin levels and low adiponectin levels, with no significant difference in the irisin levels between the groups. More comprehensive clinical studies are needed to investigate the relationship between irisin and adipokines in children.
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spelling pubmed-106732822023-11-05 Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children Esin, Kübra Batirel, Saime Ülfer, Gözde Yigit, Pakize Sanlier, Nevin Medicina (Kaunas) Article Background and Objectives: Irisin is an adipo-myokine with potential metabolic effects in the body, and its association with childhood obesity is still controversial. This study aimed to investigate the relationship between serum irisin levels and anthropometric parameters, body composition, metabolic profiles, leptin, and adiponectin in obese and normal-weight children. Methods: The study sample consisted of a total of 80 children aged 6–10, including 44 obese children (BMI ≥ 97th percentile) and 36 normal-weight children. Anthropometric parameters were measured. Body composition was determined with the use of the Bioelectrical Impedance Analysis (BIA) method. Metabolic profiles, as well as irisin, leptin, and adiponectin levels, were analyzed. Results: Anthropometric parameters and body composition were found to be significantly different between the obese and normal-weight groups (p < 0.05). Fasting blood glucose, insulin, HOMA-IR, and leptin levels were found to be significantly higher in the obese group, while the normal-weight group had significantly higher HDL cholesterol and adiponectin levels (p < 0.05). Serum irisin levels did not differ between the obese and normal-weight groups, or based on sex, vitamin D levels, and insulin resistance status. There was also no statistically significant correlation between serum irisin levels and anthropometric parameters, metabolic profile, leptin, and adiponectin. Conclusions: The study concluded that the obese children who participated in this study had high leptin levels and low adiponectin levels, with no significant difference in the irisin levels between the groups. More comprehensive clinical studies are needed to investigate the relationship between irisin and adipokines in children. MDPI 2023-11-05 /pmc/articles/PMC10673282/ /pubmed/38004003 http://dx.doi.org/10.3390/medicina59111954 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Esin, Kübra
Batirel, Saime
Ülfer, Gözde
Yigit, Pakize
Sanlier, Nevin
Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title_full Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title_fullStr Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title_full_unstemmed Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title_short Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children
title_sort association of serum irisin levels with body composition, metabolic profile, leptin, and adiponectin levels in lean and obese children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673282/
https://www.ncbi.nlm.nih.gov/pubmed/38004003
http://dx.doi.org/10.3390/medicina59111954
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