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Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity
An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high e...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673291/ https://www.ncbi.nlm.nih.gov/pubmed/38005323 http://dx.doi.org/10.3390/molecules28227602 |
| _version_ | 1785149594294812672 |
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| author | Li, Xue Chen, Xing-Yu Fan, Bing-Ying Yu, Qun Lei, Jie Xu, Zhi-Gang Chen, Zhong-Zhu |
| author_facet | Li, Xue Chen, Xing-Yu Fan, Bing-Ying Yu, Qun Lei, Jie Xu, Zhi-Gang Chen, Zhong-Zhu |
| author_sort | Li, Xue |
| collection | PubMed |
| description | An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC(50) value of 10.65 μM. |
| format | Online Article Text |
| id | pubmed-10673291 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106732912023-11-15 Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity Li, Xue Chen, Xing-Yu Fan, Bing-Ying Yu, Qun Lei, Jie Xu, Zhi-Gang Chen, Zhong-Zhu Molecules Article An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC(50) value of 10.65 μM. MDPI 2023-11-15 /pmc/articles/PMC10673291/ /pubmed/38005323 http://dx.doi.org/10.3390/molecules28227602 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Li, Xue Chen, Xing-Yu Fan, Bing-Ying Yu, Qun Lei, Jie Xu, Zhi-Gang Chen, Zhong-Zhu Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title | Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title_full | Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title_fullStr | Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title_full_unstemmed | Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title_short | Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity |
| title_sort | metal-free catalyzed oxidation/decarboxylative [3+2] cycloaddition sequences of 3-formylchromones to access pyrroles with anti-cancer activity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673291/ https://www.ncbi.nlm.nih.gov/pubmed/38005323 http://dx.doi.org/10.3390/molecules28227602 |
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