N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases

The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect h...

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Detalles Bibliográficos
Autores principales: Teng, Yan, Yi, Jin, Chen, Junnian, Yang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673353/
https://www.ncbi.nlm.nih.gov/pubmed/37903470
http://dx.doi.org/10.1159/000534162
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author Teng, Yan
Yi, Jin
Chen, Junnian
Yang, Lu
author_facet Teng, Yan
Yi, Jin
Chen, Junnian
Yang, Lu
author_sort Teng, Yan
collection PubMed
description The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory response with impacts on infectious, neoplastic, autoimmune, cardiovascular, hepatic, and osteal diseases. The current review summarizes recent research on m6A in monocyte/macrophages, neutrophils, dendritic cells, natural killer cells, and microglia and gives insights into epigenetic modifications of the immune system and novel therapeutic strategies for immune-related diseases.
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spelling pubmed-106733532023-10-30 N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases Teng, Yan Yi, Jin Chen, Junnian Yang, Lu J Innate Immun Review Article The post-transcriptional N6-methyladenosine (m6A) modification of RNA influences stability, transport, and translation with implications for various physiological and pathological processes. Immune cell development, differentiation, and activation are also thought to be regulated by m6A and affect host defense against pathogens and inflammatory response with impacts on infectious, neoplastic, autoimmune, cardiovascular, hepatic, and osteal diseases. The current review summarizes recent research on m6A in monocyte/macrophages, neutrophils, dendritic cells, natural killer cells, and microglia and gives insights into epigenetic modifications of the immune system and novel therapeutic strategies for immune-related diseases. S. Karger AG 2023-10-30 /pmc/articles/PMC10673353/ /pubmed/37903470 http://dx.doi.org/10.1159/000534162 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Review Article
Teng, Yan
Yi, Jin
Chen, Junnian
Yang, Lu
N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title_full N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title_fullStr N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title_full_unstemmed N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title_short N6-Methyladenosine (m6A) Modification in Natural Immune Cell-Mediated Inflammatory Diseases
title_sort n6-methyladenosine (m6a) modification in natural immune cell-mediated inflammatory diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673353/
https://www.ncbi.nlm.nih.gov/pubmed/37903470
http://dx.doi.org/10.1159/000534162
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