Preliminary SAR of Novel Pleuromutilin–Polyamine Conjugates

While pleuromutilin (1) and its clinically available derivatives (2–6) are highly effective against Gram-positive bacteria, they remain inactive against many pathogenic Gram-negative bacteria due to the efflux pump AcrAB-TolC. In an effort to broaden the spectrum of activity of pleuromutilin (1), we...

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Detalles Bibliográficos
Autores principales: Sue, Kenneth, Cadelis, Melissa M., Hainsworth, Kerrin, Rouvier, Florent, Bourguet-Kondracki, Marie-Lise, Brunel, Jean Michel, Copp, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673369/
https://www.ncbi.nlm.nih.gov/pubmed/38004802
http://dx.doi.org/10.3390/microorganisms11112791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673369/
https://www.ncbi.nlm.nih.gov/pubmed/38004802
http://dx.doi.org/10.3390/microorganisms11112791

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