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The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury

Background and Objectives: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. Materials and Methods: This study was conducted on 60 male Wistar albino rats (6...

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Autores principales: Glisic, Milos, Nikolic Turnic, Tamara, Zivkovic, Vladimir, Pindovic, Bozidar, Chichkova, Natalia Vasilievna, Fisenko, Vladimir Petrovich, Nikolic, Marina, Stijak, Lazar, Yurievna, Lemina Elena, Veselinovic, Mirjana, Jovicic, Milena, Mihajlovic, Katarina, Bolevich, Sergey, Jakovljevic, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673439/
https://www.ncbi.nlm.nih.gov/pubmed/38004044
http://dx.doi.org/10.3390/medicina59111995
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author Glisic, Milos
Nikolic Turnic, Tamara
Zivkovic, Vladimir
Pindovic, Bozidar
Chichkova, Natalia Vasilievna
Fisenko, Vladimir Petrovich
Nikolic, Marina
Stijak, Lazar
Yurievna, Lemina Elena
Veselinovic, Mirjana
Jovicic, Milena
Mihajlovic, Katarina
Bolevich, Sergey
Jakovljevic, Vladimir
author_facet Glisic, Milos
Nikolic Turnic, Tamara
Zivkovic, Vladimir
Pindovic, Bozidar
Chichkova, Natalia Vasilievna
Fisenko, Vladimir Petrovich
Nikolic, Marina
Stijak, Lazar
Yurievna, Lemina Elena
Veselinovic, Mirjana
Jovicic, Milena
Mihajlovic, Katarina
Bolevich, Sergey
Jakovljevic, Vladimir
author_sort Glisic, Milos
collection PubMed
description Background and Objectives: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. Materials and Methods: This study was conducted on 60 male Wistar albino rats (6 weeks old, bw: 200 ± 20 g), divided into: CTRL group—a sedentary control group; sAeT—a group that underwent aerobic swimming conditioning using a swimming protocol for 8 weeks; sAnT—a group that underwent anaerobic swimming conditioning; rAeT—a group that underwent aerobic running conditioning; and rAnT—a group that underwent anaerobic running conditioning. After the preconditioning protocols, ex vivo estimating of myocardial function according to the Langendorff technique was performed. Results: The anaerobic running training decreased heart rate and the anaerobic swimming training reduced coronary flow, demonstrating the difference in the physiological heart response of aerobic/anaerobic physical training (p < 0.05). Heart rate was significantly reduced in both training swimming groups after a period of ischemia (p < 0.05). On the other hand, the anaerobic running protocol induced a significantly decreased heart rate in comparison with the aerobic running group and the sedentary group (p < 0.05). Conclusions: The data from this experimental study support many protective training effects, i.e., improved contractility, improved resting heart rate, and increased physical work capacity and exercise tolerance. Physical training in the form of anaerobic running induces greater heart preconditioning for reperfusion injury in comparison with anaerobic swimming training.
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spelling pubmed-106734392023-11-13 The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury Glisic, Milos Nikolic Turnic, Tamara Zivkovic, Vladimir Pindovic, Bozidar Chichkova, Natalia Vasilievna Fisenko, Vladimir Petrovich Nikolic, Marina Stijak, Lazar Yurievna, Lemina Elena Veselinovic, Mirjana Jovicic, Milena Mihajlovic, Katarina Bolevich, Sergey Jakovljevic, Vladimir Medicina (Kaunas) Article Background and Objectives: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. Materials and Methods: This study was conducted on 60 male Wistar albino rats (6 weeks old, bw: 200 ± 20 g), divided into: CTRL group—a sedentary control group; sAeT—a group that underwent aerobic swimming conditioning using a swimming protocol for 8 weeks; sAnT—a group that underwent anaerobic swimming conditioning; rAeT—a group that underwent aerobic running conditioning; and rAnT—a group that underwent anaerobic running conditioning. After the preconditioning protocols, ex vivo estimating of myocardial function according to the Langendorff technique was performed. Results: The anaerobic running training decreased heart rate and the anaerobic swimming training reduced coronary flow, demonstrating the difference in the physiological heart response of aerobic/anaerobic physical training (p < 0.05). Heart rate was significantly reduced in both training swimming groups after a period of ischemia (p < 0.05). On the other hand, the anaerobic running protocol induced a significantly decreased heart rate in comparison with the aerobic running group and the sedentary group (p < 0.05). Conclusions: The data from this experimental study support many protective training effects, i.e., improved contractility, improved resting heart rate, and increased physical work capacity and exercise tolerance. Physical training in the form of anaerobic running induces greater heart preconditioning for reperfusion injury in comparison with anaerobic swimming training. MDPI 2023-11-13 /pmc/articles/PMC10673439/ /pubmed/38004044 http://dx.doi.org/10.3390/medicina59111995 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glisic, Milos
Nikolic Turnic, Tamara
Zivkovic, Vladimir
Pindovic, Bozidar
Chichkova, Natalia Vasilievna
Fisenko, Vladimir Petrovich
Nikolic, Marina
Stijak, Lazar
Yurievna, Lemina Elena
Veselinovic, Mirjana
Jovicic, Milena
Mihajlovic, Katarina
Bolevich, Sergey
Jakovljevic, Vladimir
The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title_full The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title_fullStr The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title_full_unstemmed The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title_short The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
title_sort enhanced effects of swimming and running preconditioning in an experimental model of myocardial ischemia/reperfusion injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673439/
https://www.ncbi.nlm.nih.gov/pubmed/38004044
http://dx.doi.org/10.3390/medicina59111995
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