New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus

In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica gra...

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Autores principales: Anwar, Alaa, Elnaggar, Mohamed S., Elissawy, Ahmed M., Ibrahim, Nehal, Mándi, Attila, Kurtán, Tibor, Liu, Zhen, El-Ahmady, Sherweit H., Kalscheuer, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673506/
https://www.ncbi.nlm.nih.gov/pubmed/38005373
http://dx.doi.org/10.3390/molecules28227650
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author Anwar, Alaa
Elnaggar, Mohamed S.
Elissawy, Ahmed M.
Ibrahim, Nehal
Mándi, Attila
Kurtán, Tibor
Liu, Zhen
El-Ahmady, Sherweit H.
Kalscheuer, Rainer
author_facet Anwar, Alaa
Elnaggar, Mohamed S.
Elissawy, Ahmed M.
Ibrahim, Nehal
Mándi, Attila
Kurtán, Tibor
Liu, Zhen
El-Ahmady, Sherweit H.
Kalscheuer, Rainer
author_sort Anwar, Alaa
collection PubMed
description In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica granatum fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of 1 and 2 were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound 5 displayed significant activity against methicillin-resistant Staphylococcus aureus strain ATCC 700699 and moderate activity against S. aureus strain ATCC 29213.
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spelling pubmed-106735062023-11-18 New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus Anwar, Alaa Elnaggar, Mohamed S. Elissawy, Ahmed M. Ibrahim, Nehal Mándi, Attila Kurtán, Tibor Liu, Zhen El-Ahmady, Sherweit H. Kalscheuer, Rainer Molecules Article In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica granatum fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of 1 and 2 were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound 5 displayed significant activity against methicillin-resistant Staphylococcus aureus strain ATCC 700699 and moderate activity against S. aureus strain ATCC 29213. MDPI 2023-11-18 /pmc/articles/PMC10673506/ /pubmed/38005373 http://dx.doi.org/10.3390/molecules28227650 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anwar, Alaa
Elnaggar, Mohamed S.
Elissawy, Ahmed M.
Ibrahim, Nehal
Mándi, Attila
Kurtán, Tibor
Liu, Zhen
El-Ahmady, Sherweit H.
Kalscheuer, Rainer
New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title_full New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title_fullStr New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title_full_unstemmed New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title_short New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus Talaromyces purpureogenus
title_sort new meroterpenoid derivatives from the pomegranate-derived endophytic fungus talaromyces purpureogenus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673506/
https://www.ncbi.nlm.nih.gov/pubmed/38005373
http://dx.doi.org/10.3390/molecules28227650
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