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Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis †
The preparation and use of α-(acyloxy)alkyl xanthates to generate and capture α-(acyloxy)alkyl radicals is briefly reviewed. Their inter- and intramolecular additions to both activated and unactivated, electronically unbiased, alkenes, and to (hetero)aromatic rings, as well as their radical allylati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673534/ https://www.ncbi.nlm.nih.gov/pubmed/38005282 http://dx.doi.org/10.3390/molecules28227561 |
| _version_ | 1785149616701833216 |
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| author | Quiclet-Sire, Béatrice Zard, Samir Z. |
| author_facet | Quiclet-Sire, Béatrice Zard, Samir Z. |
| author_sort | Quiclet-Sire, Béatrice |
| collection | PubMed |
| description | The preparation and use of α-(acyloxy)alkyl xanthates to generate and capture α-(acyloxy)alkyl radicals is briefly reviewed. Their inter- and intramolecular additions to both activated and unactivated, electronically unbiased, alkenes, and to (hetero)aromatic rings, as well as their radical allylation and vinylation reactions are described. Application to the total synthesis of two 4-hydroxytetralone natural products is also presented. |
| format | Online Article Text |
| id | pubmed-10673534 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106735342023-11-13 Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † Quiclet-Sire, Béatrice Zard, Samir Z. Molecules Review The preparation and use of α-(acyloxy)alkyl xanthates to generate and capture α-(acyloxy)alkyl radicals is briefly reviewed. Their inter- and intramolecular additions to both activated and unactivated, electronically unbiased, alkenes, and to (hetero)aromatic rings, as well as their radical allylation and vinylation reactions are described. Application to the total synthesis of two 4-hydroxytetralone natural products is also presented. MDPI 2023-11-13 /pmc/articles/PMC10673534/ /pubmed/38005282 http://dx.doi.org/10.3390/molecules28227561 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Quiclet-Sire, Béatrice Zard, Samir Z. Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title | Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title_full | Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title_fullStr | Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title_full_unstemmed | Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title_short | Some Aspects of α-(Acyloxy)alkyl Radicals in Organic Synthesis † |
| title_sort | some aspects of α-(acyloxy)alkyl radicals in organic synthesis † |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673534/ https://www.ncbi.nlm.nih.gov/pubmed/38005282 http://dx.doi.org/10.3390/molecules28227561 |
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