Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy

BACKGROUND: Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC) replacement therapy. Within tissues, cortisol (F) availability is under the control of the isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). We hypothesize that corticosteroid metabolism is altered in pa...

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Detalles Bibliográficos
Autores principales: Dineen, Rosemary A, Martin-Grace, Julie, Ahmed, Khalid Mohamed Saeed, Taylor, Angela E, Shaheen, Fozia, Schiffer, Lina, Gilligan, Lorna C, Lavery, Gareth G, Frizelle, Isolda, Gunness, Anjuli, Garrahy, Aoife, Hannon, Anne Marie, Methlie, Paal, Eystein, Sverre Husebye, Stewart, Paul M, Tomlinson, Jeremy W, Hawley, James M, Keevil, Brian G, O’Reilly, Michael W, Smith, Diarmuid, McDermott, John, Healy, Marie-Louise, Agha, Amar, Pazderska, Agnieszka, Gibney, James, Behan, Lucy-Ann, Thompson, Chris J, Arlt, Wiebke, Sherlock, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Clinical Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673701/
https://www.ncbi.nlm.nih.gov/pubmed/37339332
http://dx.doi.org/10.1210/clinem/dgad370

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