The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma

Metastasis remains the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC), in which sustained activation of the Notch signaling plays a critical role. N6-Methyladenosine (m6A)-mediated post-transcriptional regulation is involved in fine-tuning the Notch signaling output...

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Detalles Bibliográficos
Autores principales: Chen, Boyu, Huang, Runda, Xia, Tianliang, Wang, Chunyang, Xiao, Xiao, Lu, Shunzhen, Chen, Xiangfu, Ouyang, Ying, Deng, Xiaowu, Miao, Jingjing, Zhao, Chong, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673713/
https://www.ncbi.nlm.nih.gov/pubmed/37853162
http://dx.doi.org/10.1038/s41388-023-02865-6

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