Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts

PURPOSE: Despite new treatment options, melanoma continues to have an unfavorable prognosis. DNA damage response (DDR) inhibitors are a promising drug class, especially in combination with chemotherapy (CT) or radiotherapy (RT). Manipulating DNA damage repair during RT is an opportunity to exploit t...

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Detalles Bibliográficos
Autores principales: Scheper, Julian, Hildebrand, Laura S., Faulhaber, Eva-Maria, Deloch, Lisa, Gaipl, Udo S., Symank, Julia, Fietkau, Rainer, Distel, Luitpold V., Hecht, Markus, Jost, Tina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673781/
https://www.ncbi.nlm.nih.gov/pubmed/36229655
http://dx.doi.org/10.1007/s00066-022-02009-x

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