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Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities

Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be synthetic lethal with Polθ, but whether distinct HR gene mutati...

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Detalles Bibliográficos
Autores principales:	Krais, John J., Glass, David J., Chudoba, Ilse, Wang, Yifan, Feng, Wanjuan, Simpson, Dennis, Patel, Pooja, Liu, Zemin, Neumann-Domer, Ryan, Betsch, Robert G., Bernhardy, Andrea J., Bradbury, Alice M., Conger, Jason, Yueh, Wei-Ting, Nacson, Joseph, Pomerantz, Richard T., Gupta, Gaorav P., Testa, Joseph R., Johnson, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673838/ https://www.ncbi.nlm.nih.gov/pubmed/38001070 http://dx.doi.org/10.1038/s41467-023-43446-1

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