Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value

Where sufficiently large genome-wide association study (GWAS) samples are not currently available or feasible, methods that leverage increasing knowledge of the biological function of variants may illuminate discoveries without increasing sample size. We comprehensively evaluated 17 functional weigh...

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Detalles Bibliográficos
Autores principales: Moore, Amy, Marks, Jesse A., Quach, Bryan C., Guo, Yuelong, Bierut, Laura J., Gaddis, Nathan C., Hancock, Dana B., Page, Grier P., Johnson, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673847/
https://www.ncbi.nlm.nih.gov/pubmed/38001305
http://dx.doi.org/10.1038/s42003-023-05413-w

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