Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures

Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, such tumors have only recently been identified as a distinct entity, and biological as well as clinical charact...

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Detalles Bibliográficos
Autores principales: Schoof, Melanie, Godbole, Shweta, Albert, Thomas K., Dottermusch, Matthias, Walter, Carolin, Ballast, Annika, Qin, Nan, Olivera, Marlena Baca, Göbel, Carolin, Neyazi, Sina, Holdhof, Dörthe, Kresbach, Catena, Peter, Levke-Sophie, Epplen, Gefion Dorothea, Thaden, Vanessa, Spohn, Michael, Blattner-Johnson, Mirjam, Modemann, Franziska, Mynarek, Martin, Rutkowski, Stefan, Sill, Martin, Varghese, Julian, Afflerbach, Ann-Kristin, Eckhardt, Alicia, Münter, Daniel, Verma, Archana, Struve, Nina, Jones, David T. W., Remke, Marc, Neumann, Julia E., Kerl, Kornelius, Schüller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10673884/
https://www.ncbi.nlm.nih.gov/pubmed/38001143
http://dx.doi.org/10.1038/s41467-023-43564-w

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