PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway

During the process of wound healing, fibroblasts migrate to the wound site and perform essential functions in promoting cell proliferation, as well as synthesizing and secreting the extracellular matrix (ECM). However, in diabetic wounds, senescent fibroblasts exhibit impaired proliferative capacity...

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Detalles Bibliográficos
Autores principales: Ma, Zhouji, Ding, Youjun, Ding, Xiaofeng, Mou, Haining, Mo, Ran, Tan, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674012/
https://www.ncbi.nlm.nih.gov/pubmed/38001078
http://dx.doi.org/10.1038/s41420-023-01725-2

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