Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer

Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote tumor aggressiveness has been controversial. Ana...

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Detalles Bibliográficos
Autores principales: Serebriiskii, Ilya G., Pavlov, Valerii A., Andrianov, Grigorii V., Litwin, Samuel, Basickes, Stanley, Newberg, Justin Y., Frampton, Garrett M., Meyer, Joshua E., Golemis, Erica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674024/
https://www.ncbi.nlm.nih.gov/pubmed/38001126
http://dx.doi.org/10.1038/s41525-023-00384-7

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