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Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials

Novel core–shell magnetic molecularly imprinted polymers (MMIPs) were synthesized using the sol–gel method for the adsorption of cefixime (CFX). Fe(3)O(4)@SiO(2) is the core, and molecularly imprinted polymers (MIPs) are the shell, which can selectively interact with CFX. The preparation conditions,...

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Autores principales: Zhang, Li, Mo, Hongbo, Wang, Chuan, Li, Xiaofeng, Jiang, Shuai, Fan, Weigang, Zhang, Yagang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674183/
https://www.ncbi.nlm.nih.gov/pubmed/38006188
http://dx.doi.org/10.3390/polym15224464
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author Zhang, Li
Mo, Hongbo
Wang, Chuan
Li, Xiaofeng
Jiang, Shuai
Fan, Weigang
Zhang, Yagang
author_facet Zhang, Li
Mo, Hongbo
Wang, Chuan
Li, Xiaofeng
Jiang, Shuai
Fan, Weigang
Zhang, Yagang
author_sort Zhang, Li
collection PubMed
description Novel core–shell magnetic molecularly imprinted polymers (MMIPs) were synthesized using the sol–gel method for the adsorption of cefixime (CFX). Fe(3)O(4)@SiO(2) is the core, and molecularly imprinted polymers (MIPs) are the shell, which can selectively interact with CFX. The preparation conditions, adsorption kinetics, adsorption isotherms, selective adsorption ability, and reutilization performance of the MMIPs were investigated. The adsorption capacity of MMIPs for CFX was 111.38 mg/g, which was about 3.5 times that of MNIPs. The adsorption equilibrium time was 180 min. The dynamic adsorption experiments showed that the adsorption process of MMIPs to CFX conformed to the pseudo-second-order model. Through static adsorption study, the Scatchard analysis showed that MMIPs had two types of binding sites—the high-affinity binding sites and the low-affinity binding sites—while the Langmuir model fit the adsorption isotherms well (R(2) = 0.9962). Cefepime and ceftiofur were selected as the structural analogs of CFX for selective adsorption studies; the adsorption of CFX by MMIPs was higher than that of other structural analogs; and the imprinting factors of CFX, cefepime, and ceftiofur were 3.5, 1.7, and 1.4, respectively. Furthermore, the MMIPs also showed excellent reusable performance.
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spelling pubmed-106741832023-11-20 Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials Zhang, Li Mo, Hongbo Wang, Chuan Li, Xiaofeng Jiang, Shuai Fan, Weigang Zhang, Yagang Polymers (Basel) Article Novel core–shell magnetic molecularly imprinted polymers (MMIPs) were synthesized using the sol–gel method for the adsorption of cefixime (CFX). Fe(3)O(4)@SiO(2) is the core, and molecularly imprinted polymers (MIPs) are the shell, which can selectively interact with CFX. The preparation conditions, adsorption kinetics, adsorption isotherms, selective adsorption ability, and reutilization performance of the MMIPs were investigated. The adsorption capacity of MMIPs for CFX was 111.38 mg/g, which was about 3.5 times that of MNIPs. The adsorption equilibrium time was 180 min. The dynamic adsorption experiments showed that the adsorption process of MMIPs to CFX conformed to the pseudo-second-order model. Through static adsorption study, the Scatchard analysis showed that MMIPs had two types of binding sites—the high-affinity binding sites and the low-affinity binding sites—while the Langmuir model fit the adsorption isotherms well (R(2) = 0.9962). Cefepime and ceftiofur were selected as the structural analogs of CFX for selective adsorption studies; the adsorption of CFX by MMIPs was higher than that of other structural analogs; and the imprinting factors of CFX, cefepime, and ceftiofur were 3.5, 1.7, and 1.4, respectively. Furthermore, the MMIPs also showed excellent reusable performance. MDPI 2023-11-20 /pmc/articles/PMC10674183/ /pubmed/38006188 http://dx.doi.org/10.3390/polym15224464 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Li
Mo, Hongbo
Wang, Chuan
Li, Xiaofeng
Jiang, Shuai
Fan, Weigang
Zhang, Yagang
Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title_full Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title_fullStr Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title_full_unstemmed Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title_short Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials
title_sort synthesis and properties of cefixime core–shell magnetic nano-molecularly imprinted materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674183/
https://www.ncbi.nlm.nih.gov/pubmed/38006188
http://dx.doi.org/10.3390/polym15224464
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