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Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MA...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674227/ https://www.ncbi.nlm.nih.gov/pubmed/38004162 http://dx.doi.org/10.3390/nu15224763 |
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author | Hu, Chengxiang Huang, Rong Li, Runhong Ning, Ning He, Yue Zhang, Jiaqi Wang, Yingxin Ma, Yanan Jin, Lina |
author_facet | Hu, Chengxiang Huang, Rong Li, Runhong Ning, Ning He, Yue Zhang, Jiaqi Wang, Yingxin Ma, Yanan Jin, Lina |
author_sort | Hu, Chengxiang |
collection | PubMed |
description | Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MAFLD were evaluated utilizing a multivariable logistic regression model. Additionally, a leave-one-out model was applied to assess the effect of isocaloric substitution of specific macronutrients. Results: Participants within the highest tertile of healthy LCD scores (0.63; 95% confidence interval [CI], 0.45–0.89) or with a healthy LFD score (0.64; 95%CI, 0.48–0.86) faced a lower MAFLD risk. Furthermore, compared with tertile 1, individuals with unhealthy LFD scores in terile 2 or tertile 3 had 49% (95%CI, 1.17–1.90) and 77% (95%CI, 1.19–2.63) higher risk levels for MAFLD, respectively. Conclusions: Healthy LCD and healthy LFD are protective against MAFLD, while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients might have significant influences on MAFLD. |
format | Online Article Text |
id | pubmed-10674227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106742272023-11-13 Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease Hu, Chengxiang Huang, Rong Li, Runhong Ning, Ning He, Yue Zhang, Jiaqi Wang, Yingxin Ma, Yanan Jin, Lina Nutrients Article Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MAFLD were evaluated utilizing a multivariable logistic regression model. Additionally, a leave-one-out model was applied to assess the effect of isocaloric substitution of specific macronutrients. Results: Participants within the highest tertile of healthy LCD scores (0.63; 95% confidence interval [CI], 0.45–0.89) or with a healthy LFD score (0.64; 95%CI, 0.48–0.86) faced a lower MAFLD risk. Furthermore, compared with tertile 1, individuals with unhealthy LFD scores in terile 2 or tertile 3 had 49% (95%CI, 1.17–1.90) and 77% (95%CI, 1.19–2.63) higher risk levels for MAFLD, respectively. Conclusions: Healthy LCD and healthy LFD are protective against MAFLD, while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients might have significant influences on MAFLD. MDPI 2023-11-13 /pmc/articles/PMC10674227/ /pubmed/38004162 http://dx.doi.org/10.3390/nu15224763 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hu, Chengxiang Huang, Rong Li, Runhong Ning, Ning He, Yue Zhang, Jiaqi Wang, Yingxin Ma, Yanan Jin, Lina Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title | Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title_full | Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title_fullStr | Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title_full_unstemmed | Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title_short | Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease |
title_sort | low-carbohydrate and low-fat diet with metabolic-dysfunction-associated fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674227/ https://www.ncbi.nlm.nih.gov/pubmed/38004162 http://dx.doi.org/10.3390/nu15224763 |
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