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Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease

Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MA...

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Autores principales: Hu, Chengxiang, Huang, Rong, Li, Runhong, Ning, Ning, He, Yue, Zhang, Jiaqi, Wang, Yingxin, Ma, Yanan, Jin, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674227/
https://www.ncbi.nlm.nih.gov/pubmed/38004162
http://dx.doi.org/10.3390/nu15224763
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author Hu, Chengxiang
Huang, Rong
Li, Runhong
Ning, Ning
He, Yue
Zhang, Jiaqi
Wang, Yingxin
Ma, Yanan
Jin, Lina
author_facet Hu, Chengxiang
Huang, Rong
Li, Runhong
Ning, Ning
He, Yue
Zhang, Jiaqi
Wang, Yingxin
Ma, Yanan
Jin, Lina
author_sort Hu, Chengxiang
collection PubMed
description Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MAFLD were evaluated utilizing a multivariable logistic regression model. Additionally, a leave-one-out model was applied to assess the effect of isocaloric substitution of specific macronutrients. Results: Participants within the highest tertile of healthy LCD scores (0.63; 95% confidence interval [CI], 0.45–0.89) or with a healthy LFD score (0.64; 95%CI, 0.48–0.86) faced a lower MAFLD risk. Furthermore, compared with tertile 1, individuals with unhealthy LFD scores in terile 2 or tertile 3 had 49% (95%CI, 1.17–1.90) and 77% (95%CI, 1.19–2.63) higher risk levels for MAFLD, respectively. Conclusions: Healthy LCD and healthy LFD are protective against MAFLD, while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients might have significant influences on MAFLD.
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spelling pubmed-106742272023-11-13 Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease Hu, Chengxiang Huang, Rong Li, Runhong Ning, Ning He, Yue Zhang, Jiaqi Wang, Yingxin Ma, Yanan Jin, Lina Nutrients Article Background: This observational cross-sectional study was designed to explore the effects of a low-carbohydrate diet (LCD) and a low-fat diet (LFD) on metabolic-dysfunction-associated fatty liver disease (MAFLD). Methods: This study involved 3961 adults. The associations between LCD/LFD scores and MAFLD were evaluated utilizing a multivariable logistic regression model. Additionally, a leave-one-out model was applied to assess the effect of isocaloric substitution of specific macronutrients. Results: Participants within the highest tertile of healthy LCD scores (0.63; 95% confidence interval [CI], 0.45–0.89) or with a healthy LFD score (0.64; 95%CI, 0.48–0.86) faced a lower MAFLD risk. Furthermore, compared with tertile 1, individuals with unhealthy LFD scores in terile 2 or tertile 3 had 49% (95%CI, 1.17–1.90) and 77% (95%CI, 1.19–2.63) higher risk levels for MAFLD, respectively. Conclusions: Healthy LCD and healthy LFD are protective against MAFLD, while unhealthy LFD can increase the risk of MAFLD. Both the quantity and quality of macronutrients might have significant influences on MAFLD. MDPI 2023-11-13 /pmc/articles/PMC10674227/ /pubmed/38004162 http://dx.doi.org/10.3390/nu15224763 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Chengxiang
Huang, Rong
Li, Runhong
Ning, Ning
He, Yue
Zhang, Jiaqi
Wang, Yingxin
Ma, Yanan
Jin, Lina
Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title_full Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title_fullStr Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title_full_unstemmed Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title_short Low-Carbohydrate and Low-Fat Diet with Metabolic-Dysfunction-Associated Fatty Liver Disease
title_sort low-carbohydrate and low-fat diet with metabolic-dysfunction-associated fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674227/
https://www.ncbi.nlm.nih.gov/pubmed/38004162
http://dx.doi.org/10.3390/nu15224763
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