Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications

This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging...

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Detalles Bibliográficos
Autores principales: Nelson, Bryce J. B., Wilson, John, Andersson, Jan D., Wuest, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674391/
https://www.ncbi.nlm.nih.gov/pubmed/38004486
http://dx.doi.org/10.3390/ph16111622
Descripción
Sumario:This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: (133)La, (132)La, (134)Ce/(134)La, and (226)Ac for (225)Ac TAT; (203)Pb for (212)Pb TAT; (131)Ba for (223)Ra and (224)Ra TAT; (123)I, (124)I, (131)I and (209)At for (211)At TAT; (134)Ce/(134)La for (227)Th TAT; and (155)Tb and (152)Tb for (149)Tb TAT.

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