Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications

This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging...

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Detalles Bibliográficos
Autores principales: Nelson, Bryce J. B., Wilson, John, Andersson, Jan D., Wuest, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674391/
https://www.ncbi.nlm.nih.gov/pubmed/38004486
http://dx.doi.org/10.3390/ph16111622
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author Nelson, Bryce J. B.
Wilson, John
Andersson, Jan D.
Wuest, Frank
author_facet Nelson, Bryce J. B.
Wilson, John
Andersson, Jan D.
Wuest, Frank
author_sort Nelson, Bryce J. B.
collection PubMed
description This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: (133)La, (132)La, (134)Ce/(134)La, and (226)Ac for (225)Ac TAT; (203)Pb for (212)Pb TAT; (131)Ba for (223)Ra and (224)Ra TAT; (123)I, (124)I, (131)I and (209)At for (211)At TAT; (134)Ce/(134)La for (227)Th TAT; and (155)Tb and (152)Tb for (149)Tb TAT.
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spelling pubmed-106743912023-11-17 Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications Nelson, Bryce J. B. Wilson, John Andersson, Jan D. Wuest, Frank Pharmaceuticals (Basel) Review This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: (133)La, (132)La, (134)Ce/(134)La, and (226)Ac for (225)Ac TAT; (203)Pb for (212)Pb TAT; (131)Ba for (223)Ra and (224)Ra TAT; (123)I, (124)I, (131)I and (209)At for (211)At TAT; (134)Ce/(134)La for (227)Th TAT; and (155)Tb and (152)Tb for (149)Tb TAT. MDPI 2023-11-17 /pmc/articles/PMC10674391/ /pubmed/38004486 http://dx.doi.org/10.3390/ph16111622 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nelson, Bryce J. B.
Wilson, John
Andersson, Jan D.
Wuest, Frank
Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title_full Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title_fullStr Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title_full_unstemmed Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title_short Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
title_sort theranostic imaging surrogates for targeted alpha therapy: progress in production, purification, and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674391/
https://www.ncbi.nlm.nih.gov/pubmed/38004486
http://dx.doi.org/10.3390/ph16111622
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