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Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica

Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow characteristics and tableting problems associated with a high-drug-...

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Detalles Bibliográficos
Autores principales:	Alrobaian, Majed, Alalaiwe, Ahmed, Almalki, Ziyad S., Fayed, Mohamed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674408/ https://www.ncbi.nlm.nih.gov/pubmed/38004532 http://dx.doi.org/10.3390/pharmaceutics15112552

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