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Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities

Background: Multisystem inflammatory syndrome in children (MIS-C), a sequela of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV2), has been progressively reported worldwide, with cardiac involvement being a frequent presentation. Although the clinical and immunological characteri...

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Autores principales: Kumar, Nathella Pavan, Venkataraman, Aishwarya, Nancy, Arul, Selvaraj, Nandhini, Moideen, Kadar, Ahamed, Shaik Fayaz, Renji, Rachel Marriam, Sasidaran, Kandasamy, Kumar, Sandip, Periyakuppan, Muthiah, Sangaralingam, Thankgavelu, Varadarajan, Poovazhagi, Chelladurai, Elilarasi, Babu, Subash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674423/
https://www.ncbi.nlm.nih.gov/pubmed/38005840
http://dx.doi.org/10.3390/v15112162
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author Kumar, Nathella Pavan
Venkataraman, Aishwarya
Nancy, Arul
Selvaraj, Nandhini
Moideen, Kadar
Ahamed, Shaik Fayaz
Renji, Rachel Marriam
Sasidaran, Kandasamy
Kumar, Sandip
Periyakuppan, Muthiah
Sangaralingam, Thankgavelu
Varadarajan, Poovazhagi
Chelladurai, Elilarasi
Babu, Subash
author_facet Kumar, Nathella Pavan
Venkataraman, Aishwarya
Nancy, Arul
Selvaraj, Nandhini
Moideen, Kadar
Ahamed, Shaik Fayaz
Renji, Rachel Marriam
Sasidaran, Kandasamy
Kumar, Sandip
Periyakuppan, Muthiah
Sangaralingam, Thankgavelu
Varadarajan, Poovazhagi
Chelladurai, Elilarasi
Babu, Subash
author_sort Kumar, Nathella Pavan
collection PubMed
description Background: Multisystem inflammatory syndrome in children (MIS-C), a sequela of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV2), has been progressively reported worldwide, with cardiac involvement being a frequent presentation. Although the clinical and immunological characteristics of MIS-C with and without cardiac involvement have been described, the immunological differences between cardiac and non-cardiac MIS-C are not well understood. Methods: The levels of type 1, type 2, type 17, other proinflammatory cytokines and CC chemokines and CXC chemokines were measured using the Magpix multiplex cytokine assay system in MIS-C children with MIS-C cardiac (MIS-C (C) (n = 88)) and MIS-C non-cardiac (MIS-C (NC) (n = 64)) abnormalities. Results: MIS-C children with cardiac manifestations presented with significantly increased levels of cytokines such as IFN-γ, IL-2, TNFα, IL-5, IL-1α, IL-1β, IL-6, IL-10 and IL-12p70 and chemokines such as CCL2, CCL3, CCL11 and CXCL10 in comparison to MIS-C children without cardiac manifestations. Clustering analysis revealed that cytokines and chemokines could clearly distinguish MIS-C children with and without cardiac manifestations. In addition, these responses significantly diminished and normalized 9 months after treatment. Conclusions: This is one of the first studies characterizing and differentiating systemic inflammation in MIS-C with and without cardiac involvement from a low- and middle-income country (LMIC). Our study contributes to the existing body of evidence and advances our knowledge of the immunopathogenesis of MIS-C in children.
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spelling pubmed-106744232023-10-27 Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities Kumar, Nathella Pavan Venkataraman, Aishwarya Nancy, Arul Selvaraj, Nandhini Moideen, Kadar Ahamed, Shaik Fayaz Renji, Rachel Marriam Sasidaran, Kandasamy Kumar, Sandip Periyakuppan, Muthiah Sangaralingam, Thankgavelu Varadarajan, Poovazhagi Chelladurai, Elilarasi Babu, Subash Viruses Article Background: Multisystem inflammatory syndrome in children (MIS-C), a sequela of severe acute respiratory syndrome coronavirus-2 infection (SARS-CoV2), has been progressively reported worldwide, with cardiac involvement being a frequent presentation. Although the clinical and immunological characteristics of MIS-C with and without cardiac involvement have been described, the immunological differences between cardiac and non-cardiac MIS-C are not well understood. Methods: The levels of type 1, type 2, type 17, other proinflammatory cytokines and CC chemokines and CXC chemokines were measured using the Magpix multiplex cytokine assay system in MIS-C children with MIS-C cardiac (MIS-C (C) (n = 88)) and MIS-C non-cardiac (MIS-C (NC) (n = 64)) abnormalities. Results: MIS-C children with cardiac manifestations presented with significantly increased levels of cytokines such as IFN-γ, IL-2, TNFα, IL-5, IL-1α, IL-1β, IL-6, IL-10 and IL-12p70 and chemokines such as CCL2, CCL3, CCL11 and CXCL10 in comparison to MIS-C children without cardiac manifestations. Clustering analysis revealed that cytokines and chemokines could clearly distinguish MIS-C children with and without cardiac manifestations. In addition, these responses significantly diminished and normalized 9 months after treatment. Conclusions: This is one of the first studies characterizing and differentiating systemic inflammation in MIS-C with and without cardiac involvement from a low- and middle-income country (LMIC). Our study contributes to the existing body of evidence and advances our knowledge of the immunopathogenesis of MIS-C in children. MDPI 2023-10-27 /pmc/articles/PMC10674423/ /pubmed/38005840 http://dx.doi.org/10.3390/v15112162 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kumar, Nathella Pavan
Venkataraman, Aishwarya
Nancy, Arul
Selvaraj, Nandhini
Moideen, Kadar
Ahamed, Shaik Fayaz
Renji, Rachel Marriam
Sasidaran, Kandasamy
Kumar, Sandip
Periyakuppan, Muthiah
Sangaralingam, Thankgavelu
Varadarajan, Poovazhagi
Chelladurai, Elilarasi
Babu, Subash
Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title_full Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title_fullStr Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title_full_unstemmed Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title_short Immune Profiles in Multisystem Inflammatory Syndrome in Children with Cardiovascular Abnormalities
title_sort immune profiles in multisystem inflammatory syndrome in children with cardiovascular abnormalities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674423/
https://www.ncbi.nlm.nih.gov/pubmed/38005840
http://dx.doi.org/10.3390/v15112162
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